MFAP4 and RNF115

Data Source:
BioGRID (two hybrid)

		MFAP4	RNF115
Description		microfibril associated protein 4	ring finger protein 115
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix Elastic Fiber	Cytosol
	Molecular Function	Antigen Binding Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Derivative Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Complement Activation, Lectin Pathway Cell Adhesion UV Protection Regulation Of Collagen Metabolic Process Elastic Fiber Assembly Cellular Response To UV-B Supramolecular Fiber Organization	Protein Polyubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		Molecules associated with elastic fibres	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Youthful appearance (self-reported) ( 32339537)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: RNF115 SFTPD	32 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2W USP9X VCP ZNRD2
Entrez ID		4239	27246
HPRD ID		02789	18328
Ensembl ID		ENSG00000166482	ENSG00000265491
Uniprot IDs		A0A024QZ34 P55083	Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?
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