MCM4 and MCM8

Data Source:
HPRD (in vivo)

		MCM4	MCM8
Description		minichromosome maintenance complex component 4	minichromosome maintenance 8 homologous recombination repair factor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Membrane MCM Complex CMG Complex	Nucleus Nucleoplasm Chromosome Cytosol MCM Complex MCM8-MCM9 Complex
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding	DNA Helicase Activity Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication Mitotic DNA Replication Initiation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication Cellular Response To DNA Damage Stimulus Female Gamete Generation DNA Duplex Unwinding Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Protein Localization To Chromatin
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)	Breast cancer ( 29059683) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)
Interacting Genes		27 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 RPA1 SSRP1 SUMO2 SUPT16H TLX2	4 interacting genes: FEM1C MCM4 MCM6 MCM7
Entrez ID		4173	84515
HPRD ID		09094	12186
Ensembl ID		ENSG00000104738	ENSG00000125885
Uniprot IDs		B3KMX0 B4DLA6 P33991	B4DN82 Q9UJA3
PDB IDs		6XTX 6XTY	6L0O
Enriched GO Terms of Interacting Partners?
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