MARK1 and CCR6

Data Source:
BioGRID (biochemical)

		MARK1	CCR6
Description		microtubule affinity regulating kinase 1	C-C motif chemokine receptor 6
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Dendrite	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane
	Molecular Function	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau Protein Binding Tau-protein Kinase Activity Phosphatidic Acid Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Protein Phosphorylation Cytoskeleton Organization Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Intracellular Signal Transduction Regulation Of Dendrite Development Establishment Of Mitochondrion Localization	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Epithelial Cell Migration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Fostamatinib
Diseases
GWAS		Bipolar disorder ( 22205951) Breast size ( 27182965) Fat distribution (HIV) ( 21897333)	Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 18587394 28067908 20570966 21102463 23850713) Graves' disease ( 22922229) Inflammatory bowel disease ( 27569725 28067908 23128233) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 20526339 27723757)
Interacting Genes		10 interacting genes: CCDC102B GJA5 INCA1 MAP2 MAP4 MAPT STK11 TAOK1 TCL1B YAF2	5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1
Entrez ID		4139	1235
HPRD ID		07353	03498
Ensembl ID		ENSG00000116141	ENSG00000112486
Uniprot IDs		A0A087X0I6 B4DIB3 Q9P0L2 X5D2M4	P51684
PDB IDs		2HAK 3OSE 6C9D	6WWZ
Enriched GO Terms of Interacting Partners?
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