CCR6 and QSOX1

Data Source:
BioGRID (two hybrid)

		CCR6	QSOX1
Description		C-C motif chemokine receptor 6	quiescin sulfhydryl oxidase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Integral Component Of Golgi Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Intracellular Membrane-bounded Organelle Intercellular Bridge Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity	Protein Disulfide Isomerase Activity Flavin-linked Sulfhydryl Oxidase Activity FAD Binding
	Biological Process	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Epithelial Cell Migration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	Platelet Degranulation Protein Folding Negative Regulation Of Macroautophagy Protein Phosphopantetheinylation Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Extracellular Matrix Assembly
Pathways		Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 18587394 28067908 20570966 21102463 23850713) Graves' disease ( 22922229) Inflammatory bowel disease ( 27569725 28067908 23128233) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 20526339 27723757)	Anorexia nervosa ( 23568457) Blood protein levels ( 29875488) Pulse pressure ( 30224653 30578418)
Interacting Genes		5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1	6 interacting genes: BEGAIN CCR1 CCR6 CHRM4 UBE2D2 UBQLN4
Entrez ID		1235	5768
HPRD ID		03498	06785
Ensembl ID		ENSG00000112486	ENSG00000116260
Uniprot IDs		P51684	A0A140VKE5 O00391 Q13876
PDB IDs		6WWZ	3LLI 3LLK 3Q6O 4IJ3
Enriched GO Terms of Interacting Partners?
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