MIR17 and PRMT1

Data Source:
BioGRID (unspecified method)

		MIR17	PRMT1
Description		microRNA 17	protein arginine methyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion Extracellular Exosome Extracellular Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome
	Molecular Function	MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Mitogen-activated Protein Kinase P38 Binding S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Morphogenesis Negative Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Toll-like Receptor Signaling Pathway Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Pressure Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phagocytosis Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptosome Assembly Positive Regulation Of Pulmonary Blood Vessel Remodeling Positive Regulation Of Smooth Muscle Hypertrophy Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Negative Regulation Of Cellular Senescence Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	In Utero Embryonic Development Protein Methylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hemoglobin Biosynthetic Process Protein Homooligomerization Positive Regulation Of P38MAPK Cascade
Pathways			RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS			Schizophrenia ( 29483656)
Interacting Genes		84 interacting genes: AIMP1 APOBEC3B ATXN2L C1QBP CELF1 CPSF6 CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRMT1L UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZNF346	151 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GLI1 GPATCH2L GRHL3 GRIP1 H3C1 H4-16 H4C14 HABP4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR138-1 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR206 MIR20A MIR20B MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR34A MIR34C MIR363 MIR451A MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PRMT8 QKI RBM15 RELA RNF187 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A STUB1 SUPT5H TBX6 TERF2 THRB TP53 TRIM48 UBE4B VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451
Entrez ID		406952	3276
HPRD ID			04257
Ensembl ID		ENSG00000284536	ENSG00000126457
Uniprot IDs			Q99873
PDB IDs			6NT2
Enriched GO Terms of Interacting Partners?
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