LYZ and A2M

Data Source:
HPRD (in vitro)

		LYZ	A2M
Description		lysozyme	alpha-2-macroglobulin
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome Tertiary Granule Lumen	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Lysozyme Activity Identical Protein Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	Retina Homeostasis Inflammatory Response Antimicrobial Humoral Response Cytolysis Killing Of Cells Of Other Organism Defense Response To Bacterium Neutrophil Degranulation Cellular Protein Metabolic Process Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Neutrophil degranulation Antimicrobial peptides Amyloid fiber formation	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly
Drugs		Aspartic acid (R)-Propylene glycol 4-methyl-umbelliferyl-N-acetyl-chitobiose Sucrose Arsanilic acid 4)-N-acetyl-beta-D-glucosamine p-Toluenesulfonic acid Propyl alcohol Cu-Cyclam (S)-Aspartimide Dodecyl sulfate Triacetylchitotriose Methylumbelliferyl chitotriose UNDECA-3,7-DIENE-1,3,7,11-TETRACARBALDEHYDE	Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Familial amyloidosis
GWAS		Blood protein levels ( 30072576 29875488 28240269) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 18391951) Medication use (calcium channel blockers) ( 31015401) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Response to diuretic therapy ( 18591461) Triglyceride levels ( 32203549) White blood cell count ( 32888494)	Refractive error ( 32231278)
Interacting Genes		6 interacting genes: A2M CDC42 CLU ELN LCN1 LTF	96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS
Entrez ID		4069	2
HPRD ID		01085	00072
Ensembl ID		ENSG00000090382	ENSG00000175899
Uniprot IDs		B2R4C5 P61626	P01023
PDB IDs		133L 134L 1B5U 1B5V 1B5W 1B5X 1B5Y 1B5Z 1B7L 1B7M 1B7N 1B7O 1B7P 1B7Q 1B7R 1B7S 1BB3 1BB4 1BB5 1C43 1C45 1C46 1C7P 1CJ6 1CJ7 1CJ8 1CJ9 1CKC 1CKD 1CKF 1CKG 1CKH 1D6P 1D6Q 1DI3 1DI4 1DI5 1EQ4 1EQ5 1EQE 1GAY 1GAZ 1GB0 1GB2 1GB3 1GB5 1GB6 1GB7 1GB8 1GB9 1GBO 1GBW 1GBX 1GBY 1GBZ 1GDW 1GDX 1GE0 1GE1 1GE2 1GE3 1GE4 1GEV 1GEZ 1GF0 1GF3 1GF4 1GF5 1GF6 1GF7 1GF8 1GF9 1GFA 1GFE 1GFG 1GFH 1GFJ 1GFK 1GFR 1GFT 1GFU 1GFV 1HNL 1I1Z 1I20 1I22 1INU 1IOC 1IP1 1IP2 1IP3 1IP4 1IP5 1IP6 1IP7 1IWT 1IWU 1IWV 1IWW 1IWX 1IWY 1IWZ 1IX0 1IY3 1IY4 1JKA 1JKB 1JKC 1JKD 1JSF 1JWR 1LAA 1LHH 1LHI 1LHJ 1LHK 1LHL 1LHM 1LMT 1LOZ 1LYY 1LZ1 1LZ4 1LZ5 1LZ6 1LZR 1LZS 1OP9 1OUA 1OUB 1OUC 1OUD 1OUE 1OUF 1OUG 1OUH 1OUI 1OUJ 1QSW 1RE2 1REM 1REX 1REY 1REZ 1TAY 1TBY 1TCY 1TDY 1UBZ 1W08 1WQM 1WQN 1WQO 1WQP 1WQQ 1WQR 1YAM 1YAN 1YAO 1YAP 1YAQ 207L 208L 2BQA 2BQB 2BQC 2BQD 2BQE 2BQF 2BQG 2BQH 2BQI 2BQJ 2BQK 2BQL 2BQM 2BQN 2BQO 2HEA 2HEB 2HEC 2HED 2HEE 2HEF 2LHM 2MEA 2MEB 2MEC 2MED 2MEE 2MEF 2MEG 2MEH 2MEI 2NWD 2ZIJ 2ZIK 2ZIL 2ZWB 3EBA 3FE0 3LHM 3LN2 4I0C 4ML7 4R0P 5LSH 5LVK 6LFH	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?
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