MIRLET7G and DHX36

Data Source:
BioGRID (unspecified method)

		MIRLET7G	DHX36
Description		microRNA let-7g	DEAH-box helicase 36
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Chromosome, Telomeric Region Intracellular Anatomical Structure Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Perikaryon Extracellular Exosome
	Molecular Function	MRNA Binding Involved In Posttranscriptional Gene Silencing	Magnesium Ion Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding G-quadruplex RNA Binding DNA Helicase Activity Single-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA 3'-UTR Binding Protein Binding ATP Binding DNA-dependent ATPase Activity MRNA 3'-UTR AU-rich Region Binding Histone Deacetylase Binding MRNA 5'-UTR Binding G-quadruplex DNA Binding Telomerase RNA Binding Pre-miRNA Binding
	Biological Process	Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Gene Silencing By MiRNA Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Response To Glucose Stimulus Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Ossification Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Regulation Of Transcription By RNA Polymerase III Spermatogenesis RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Interferon-alpha Production Cellular Response To Heat Cellular Response To UV Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Regulation Of MRNA Stability G-quadruplex DNA Unwinding Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Defense Response To Virus Positive Regulation Of Cardioblast Differentiation Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Dendritic Spine Morphogenesis 3'-UTR-mediated MRNA Destabilization Telomerase RNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spermatogenesis Cellular Response To Arsenite Ion Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Intracellular MRNA Localization Positive Regulation Of Cytoplasmic Translation
Pathways			DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 23974872)	Blood protein levels ( 29875488) Body mass index ( 29273807) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		116 interacting genes: ADARB1 APOBEC3B AQR ATXN2L C1QBP CCAR1 CDC40 CDC5L CELF1 CHERP CPSF1 CRTAP CSTF3 DARS1 DDX1 DDX21 DDX23 DDX3X DDX3Y DHX36 DHX37 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PAXBP1 PDCD11 PLOD1 PLRG1 PTBP1 PTCD3 PUF60 PUM1 PUM2 PURA PURB QARS1 RARS1 RBFOX2 RBM10 RBM12B RBM14 RBM17 RBM4 RBM4B RBM5 RBM6 RBMS1 RTCA RTCB SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SFPQ SPOUT1 STRBP SUGP1 SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 XAB2 YBX1 YBX2 YBX3 ZFR	71 interacting genes: DUX4 IL7R MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I TLR1 ZFP36
Entrez ID		406890	170506
HPRD ID			09918
Ensembl ID		ENSG00000199150	ENSG00000174953
Uniprot IDs			Q9H2U1
PDB IDs			2N16 2N21 6Q6R
Enriched GO Terms of Interacting Partners?
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