INPP5D and KRTAP10-7

Data Source:
BioGRID (two hybrid)

		INPP5D	KRTAP10-7
Description		inositol polyphosphate-5-phosphatase D	keratin associated protein 10-7
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Membrane Raft	Cytosol Keratin Filament
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Protein Binding Identical Protein Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Leukocyte Migration	Keratinization
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling	Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		45 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17	282 interacting genes: AEN ALDH3B1 ANKRD36BP1 AP1M1 APP AQP1 AVPI1 B4GALT7 BAHD1 BCL6B BMP7 BRME1 BUD31 BYSL C8orf33 CARHSP1 CATIP CBX2 CCDC185 CCDC26 CCNG1 CDCA7L CHIC2 CHRD CHRNG CLK1 CLK4 CNNM3 COL8A1 CRCT1 CREB5 CRY2 CSNK1G1 CSNK1G2 CTNNBIP1 CTRC CXCL16 CYSRT1 DAAM2 DERL2 DHX57 DMRT3 DOCK2 E2F6 E4F1 EHHADH FADS6 FAM124B FAM161A FAM27E3 FAM74A4 FAM76B FARS2 GABARAPL1 GABARAPL2 GEM GLIDR GLP1R GNE GOLGA8EP GRN GSTP1 GUCD1 HBZ HCK HHEX HOXA1 HOXC8 HPCAL1 HSBP1 HSD3B7 IGSF8 ING5 INPP5D IQUB ITGB4 ITGB5 KLHL38 KRT20 KRT83 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP26-1 KRTAP4-2 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1F LCE2A LCE2B LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LIMS2 LINC00242 LMNA LMO2 LRCH4 MAPKBP1 MCM5 MCRS1 MOBP MRGBP MXD3 MXI1 MYPOP NAA10 NAXD NECTIN2 NECTIN3 NKD1 NOL12 NOTCH2NLA NPBWR2 NPDC1 NTAQ1 NUBP2 NUDCD3 NUFIP2 OTX1 P2RY6 PCED1A PCSK5 PDE9A PDIA5 PDLIM5 PFKL PGAP6 PHLDA1 PIN1 POLL POM121L8P PPARD PRKAB2 PRM2 PRR13 PRR35 PTGDS PTGER3 PTPMT1 PVR R3HDM2 RNF175 RPF1 RPL11 RPL36AL RPS28 RPUSD3 RSPO2 RTN4RL1 RWDD2B SCNM1 SDCBP SHFL SLC23A1 SLC25A48 SLC6A20 SMCO4 SMCP SPACA9 SPATA24 SPATA3 SPATA8 SPG7 SPRY1 SSX2IP STAT3 STK16 SUV39H1 TAPBPL TCEA2 TCEANC TEDC2 TFAP2D THAP1 THAP6 TLE5 TMA16 TNP2 TNS2 TOR1A TREX1 TRIM42 TTPA TULP3 TXNDC5 TYRO3 UCP2 UXT VASN VGLL3 VTI1B WNT11 WT1 ZBTB24 ZBTB38 ZBTB48 ZBTB9 ZFP41 ZFYVE26 ZIM2 ZNF101 ZNF124 ZNF133 ZNF138 ZNF155 ZNF165 ZNF169 ZNF175 ZNF180 ZNF2 ZNF20 ZNF223 ZNF250 ZNF256 ZNF26 ZNF260 ZNF264 ZNF266 ZNF32 ZNF320 ZNF329 ZNF337 ZNF408 ZNF41 ZNF414 ZNF417 ZNF418 ZNF419 ZNF420 ZNF425 ZNF433 ZNF439 ZNF440 ZNF444 ZNF490 ZNF491 ZNF524 ZNF543 ZNF555 ZNF564 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF625 ZNF667 ZNF670 ZNF696 ZNF697 ZNF707 ZNF764 ZNF774 ZNF778 ZNF786 ZNF792 ZNF837 ZNF844 ZNF846 ZNHIT1 ZSCAN10 ZSCAN21 ZSCAN26
Entrez ID		3635	386675
HPRD ID		09033	11193
Ensembl ID		ENSG00000168918	ENSG00000272804
Uniprot IDs		Q92835	P60409
PDB IDs		2YSX 6IBD 6XY7
Enriched GO Terms of Interacting Partners?
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