LMNB1 and KPNA1

Data Source:
BioGRID (two hybrid)

		LMNB1	KPNA1
Description		lamin B1	karyopherin subunit alpha 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Matrix Nuclear Membrane	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Phospholipase Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Interleukin-12-mediated Signaling Pathway	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Modulation By Virus Of Host Cellular Process Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway
Pathways		Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)	Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		44 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA1 KPNA5 KPNA6 LBR LMNA LMNB2 M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ	45 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMNB1 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1
Entrez ID		4001	3836
HPRD ID		01036	02819
Ensembl ID		ENSG00000113368	ENSG00000114030
Uniprot IDs		B4DZT3 P20700	B3KXZ2 P52294
PDB IDs		2KPW 3JT0 3TYY 3UMN 5VVX	2JDQ 3TJ3 4B18 6WX9
Enriched GO Terms of Interacting Partners?
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