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LMNB1 and MELK
Data Source:
HPRD
(in vivo)
LMNB1
MELK
Description
lamin B1
maternal embryonic leucine zipper kinase
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Lamin Filament
Nucleoplasm
Membrane
Nuclear Matrix
Nuclear Membrane
Nucleus
Cytoplasm
Plasma Membrane
Cell Cortex
Membrane
Molecular Function
Structural Molecule Activity
Protein Binding
Phospholipase Binding
Sequence-specific Double-stranded DNA Binding
Protein Serine/threonine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Lipid Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Interleukin-12-mediated Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Protein Phosphorylation
Apoptotic Process
Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Protein Autophosphorylation
Neural Precursor Cell Proliferation
Pathways
Meiotic synapsis
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Nuclear Envelope Breakdown
Initiation of Nuclear Envelope (NE) Reformation
Breakdown of the nuclear lamina
Depolymerisation of the Nuclear Lamina
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Fostamatinib
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Body fat percentage (
31752434
)
Parkinson's disease (motor and cognition) (
22658654
)
Interacting Genes
44 interacting genes:
ABCG8
ATF4
CASP3
CASP6
CCDC88B
CDK1
CENPH
DMAP1
FAM169A
GABARAP
GIT2
GZMA
GZMB
KPNA1
KPNA5
KPNA6
LBR
LMNA
LMNB2
M1AP
MAP1LC3A
MAP1LC3C
MBIP
MELK
PIAS2
PIH1D2
PLEC
PPP1R13B
PRKCA
PRKCB
PRKCD
PRPH
PTEN
RNF123
SERPINA3
SNAPIN
SRPK2
SUMO4
TMPO
TOR1AIP1
TP53BP2
UBE2I
URB2
YWHAQ
11 interacting genes:
CDC25B
CDC5L
EIF2S1
EZH2
H1-5
LMNB1
MAPT
MBP
PPP1R8
SF3B1
ZNF622
Entrez ID
4001
9833
HPRD ID
01036
06119
Ensembl ID
ENSG00000113368
ENSG00000165304
Uniprot IDs
B4DZT3
P20700
B7Z1G6
Q14680
PDB IDs
2KPW
3JT0
3TYY
3UMN
5VVX
4BKY
4BKZ
4BL1
4D2P
4D2T
4D2V
4D2W
4IXP
4UMP
4UMQ
4UMR
4UMT
4UMU
5IH8
5IH9
5IHA
5IHC
5K00
5M5A
5MAF
5MAG
5MAH
5MAI
5TVT
5TWL
5TWU
5TWY
5TWZ
5TX3
6GVX
6VXR
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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