LIFR and CTF1

Data Source:
HPRD (in vivo)

		LIFR	CTF1
Description		LIF receptor subunit alpha	cardiotrophin 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex Extracellular Exosome	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding	Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Cell Surface Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Neuron Development Leukemia Inhibitory Factor Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Stuve-Wiedemann syndrome
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)	Red blood cell count ( 27863252) Triglyceride levels ( 28334899) Triglycerides ( 24097068 20686565)
Interacting Genes		12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	5 interacting genes: APP EP300 IL6ST LIFR MAGEA6
Entrez ID		3977	1489
HPRD ID		01048	02699
Ensembl ID		ENSG00000113594	ENSG00000150281
Uniprot IDs		A8K1Z4 P42702	Q16619
PDB IDs		3E0G
Enriched GO Terms of Interacting Partners?
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