LIFR and CNTFR

Data Source:
HPRD (in vitro)

		LIFR	CNTFR
Description		LIF receptor subunit alpha	ciliary neurotrophic factor receptor
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex CNTFR-CLCF1 Complex
	Molecular Function	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Signaling Receptor Binding Protein Binding Cytokine Binding
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway	Suckling Behavior Brainstem Development Signal Transduction Nervous System Development Sex Differentiation Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Skeletal Muscle Organ Development Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling	IL-6-type cytokine receptor ligand interactions
Drugs
Diseases		Stuve-Wiedemann syndrome
GWAS		Blood protein levels ( 30072576) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Pursuit maintenance gain ( 29064472) Ulcerative colitis ( 26192919)	Blood protein levels ( 30072576 29875488) Physiological traits ( 31902109)
Interacting Genes		12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6	9 interacting genes: APPBP2 CLCF1 CNTF CRLF1 IL6ST JPT2 KRTAP4-12 LIFR PLSCR1
Entrez ID		3977	1271
HPRD ID		01048	00348
Ensembl ID		ENSG00000113594	ENSG00000122756
Uniprot IDs		A8K1Z4 P42702	P26992
PDB IDs		3E0G	1UC6
Enriched GO Terms of Interacting Partners?
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