CTF1 and IL6ST

Data Source:
HPRD (in vivo)

		CTF1	IL6ST
Description		cardiotrophin 1	interleukin 6 cytokine family signal transducer
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Identical Protein Binding Interleukin-27 Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Cell-cell Signaling Muscle Organ Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Neuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Neuron Development Leukemia Inhibitory Factor Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions	Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Red blood cell count ( 27863252) Triglyceride levels ( 28334899) Triglycerides ( 24097068 20686565)	Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Rheumatoid arthritis ( 20453842)
Interacting Genes		5 interacting genes: APP EP300 IL6ST LIFR MAGEA6	34 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		1489	3572
HPRD ID		02699	02824
Ensembl ID		ENSG00000150281	ENSG00000134352
Uniprot IDs		Q16619	A0A0A0N0L2 P40189 Q17RA0
PDB IDs			1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?
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