MAP4K1 and DAPP1

Data Source:
HPRD (in vitro, in vivo)

		MAP4K1	DAPP1
Description		mitogen-activated protein kinase kinase kinase kinase 1	dual adaptor of phosphotyrosine and 3-phosphoinositides 1
Image
GO Annotations	Cellular Component	Membrane	Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Cell Population Proliferation Peptidyl-serine Phosphorylation Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate	Protein Dephosphorylation Signal Transduction
Pathways			Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Fostamatinib	Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Red cell distribution width ( 32888494)
Interacting Genes		22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101	23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1
Entrez ID		11184	27071
HPRD ID		03583	05773
Ensembl ID		ENSG00000104814	ENSG00000070190
Uniprot IDs		Q92918	J3KNB3 Q9UN19
PDB IDs		6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0	1FAO 1FB8
Enriched GO Terms of Interacting Partners?
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