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MAP4K1 and MAP3K7
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
MAP4K1
MAP3K7
Description
mitogen-activated protein kinase kinase kinase kinase 1
mitogen-activated protein kinase kinase kinase 7
Image
GO Annotations
Cellular Component
Membrane
Nucleus
Ada2/Gcn5/Ada3 Transcription Activator Complex
Cytosol
Plasma Membrane
IkappaB Kinase Complex
Endosome Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Scaffold Protein Binding
Biological Process
Activation Of MAPKKK Activity
Protein Phosphorylation
Activation Of JUN Kinase Activity
Cell Population Proliferation
Peptidyl-serine Phosphorylation
Protein Autophosphorylation
Cellular Response To Phorbol 13-acetate 12-myristate
Activation Of MAPKK Activity
Activation Of MAPK Activity
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
I-kappaB Kinase/NF-kappaB Signaling
Activation Of NF-kappaB-inducing Kinase Activity
I-kappaB Phosphorylation
JNK Cascade
Viral Process
Positive Regulation Of Macroautophagy
Protein Deubiquitination
Positive Regulation Of Interleukin-2 Production
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Anoikis
Positive Regulation Of JUN Kinase Activity
Histone H3 Acetylation
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Pathways
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Fostamatinib
Diseases
GWAS
Diisocyanate-induced asthma (
25918132
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
31959851
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Interacting Genes
22 interacting genes:
ABL1
BLNK
CARD11
CASP3
CRK
CRKL
DAPP1
DBNL
EGFR
GRAP2
GRB2
H2AC4
HCLS1
LAT
LCP2
LYN
MAP3K11
MAP3K7
NCK1
SHC1
SYK
TMEM101
67 interacting genes:
AKTIP
BBS10
BCL10
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FOS
GPR25
HGS
HIPK2
IKBKB
IKBKG
IL17RD
IRAK1
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
TAB1
TAB2
TAB3
TGFBR1
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
VRK2
XIAP
ZNF593
ZNF746
Entrez ID
11184
6885
HPRD ID
03583
04011
Ensembl ID
ENSG00000104814
ENSG00000135341
Uniprot IDs
Q92918
O43318
PDB IDs
6CQD
6CQE
6CQF
6NFY
6NFZ
6NG0
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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