AIF1 and LCP1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		AIF1	LCP1
Description		allograft inflammatory factor 1	lymphocyte cytosolic protein 1
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GO Annotations	Cellular Component	Ruffle Phagocytic Cup Nucleus Cytoplasm Cytosol Actin Filament Lamellipodium Ruffle Membrane Perinuclear Region Of Cytoplasm	Stress Fiber Ruffle Phagocytic Cup Podosome Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Cell Junction Filopodium Actin Filament Bundle Ruffle Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Molecular_function Calcium Ion Binding Protein Binding Actin Filament Binding	Actin Binding Integrin Binding Calcium Ion Binding Identical Protein Binding Actin Filament Binding GTPase Binding
	Biological Process	Microglial Cell Activation Phagocytosis, Engulfment Inflammatory Response Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Rac Protein Signal Transduction Actin Filament Polymerization Parallel Actin Filament Bundle Assembly Positive Regulation Of Cell Migration Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Cellular Response To Oxidative Stress Positive Regulation Of T Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Chemotaxis Actin Filament Bundle Assembly Actin Crosslink Formation Cellular Response To Interferon-gamma Negative Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Fibroblast Growth Factor Production Ruffle Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of T Cell Migration	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Extracellular Matrix Disassembly Cortical Actin Cytoskeleton Organization Animal Organ Regeneration Regulation Of Intracellular Protein Transport Interleukin-12-mediated Signaling Pathway Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly Actin Filament Network Formation Actin Crosslink Formation Positive Regulation Of Podosome Assembly
Pathways			Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Crohn's disease ( 22936669) Heel bone mineral density ( 30598549) Height ( 23563607) Inflammatory bowel disease ( 28067908) Laryngeal squamous cell carcinoma ( 25194280) Malaria ( 31844061) Mean platelet volume ( 32888494) Neonatal lupus ( 20662065) Oral cavity cancer ( 27749845) Platelet count ( 32888494) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908) Weight ( 19079260)	Blood protein levels ( 30072576 28240269) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Non-alcoholic fatty liver disease histology (other) ( 23213074) Platelet count ( 32888494) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26502338)
Interacting Genes		2 interacting genes: ACTA1 LCP1	5 interacting genes: AIF1 ATXN2 CNN3 GCA PRKACA
Entrez ID		199	3936
HPRD ID		03496	01082
Ensembl ID		ENSG00000204472	ENSG00000136167
Uniprot IDs		I3WTX1 P55008 Q4V347	A0A024RDT4 P13796
PDB IDs		2D58 2G2B	2D85 5JOJ 5JOL
Enriched GO Terms of Interacting Partners?
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