LCK and ERBB3

Data Source:
BioGRID (pull down)

		LCK	ERBB3
Description		LCK proto-oncogene, Src family tyrosine kinase	erb-b2 receptor tyrosine kinase 3
Image
GO Annotations	Cellular Component	Pericentriolar Material Immunological Synapse Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane ERBB3:ERBB2 Complex Receptor Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Serine/threonine Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding ATPase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Tyrosine Kinase Activator Activity Ubiquitin Protein Ligase Binding Neuregulin Receptor Activity Neuregulin Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Cellular Zinc Ion Homeostasis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Hemopoiesis Cell Differentiation Platelet Activation T Cell Differentiation T Cell Costimulation Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Drug Innate Immune Response Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Leukocyte Migration Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Lymphocyte Activation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	MAPK Cascade Endocardial Cushion Development Negative Regulation Of Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Peripheral Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Signal Transduction Positive Regulation Of Gene Expression Schwann Cell Differentiation Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cranial Nerve Development Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Wound Healing Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Secretion Neuron Apoptotic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Motility
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Nef Mediated CD4 Down-regulation Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway CTLA4 inhibitory signaling PD-1 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-2 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants FLT3 signaling through SRC family kinases
Drugs		Dasatinib AP-22408 Staurosporine 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid Phosphoaminophosphonic Acid-Adenylate Ester 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine Ponatinib Nintedanib Fostamatinib Zanubrutinib	Tucatinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency	Lethal congenital contractural syndrome (LCCS) Type I diabetes mellitus
GWAS		Multiple sclerosis ( 31604244)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Alopecia areata ( 25608926) Anorexia nervosa ( 28494655) Asthma ( 31959851 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Household income (MTAG) ( 31844048) Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Polycystic ovary syndrome ( 26416764) Refractive error ( 32231278) Smoking initiation ( 30617275) Type 1 diabetes ( 21829393 19430480 18198356 17554260 17554300 30572963 18978792) Vitiligo ( 22951725)
Interacting Genes		143 interacting genes: ACP1 ADAM15 AJUBA AR ARHGAP17 ASB9 AXL BCAR1 BRCA1 C1QTNF2 CBL CCR5 CD2 CD247 CD28 CD38 CD3E CD4 CD44 CD48 CD5 CD55 CD79A CD79B CD8A CDC25C CDC42 CDC45 CDKAL1 CSF2RB CSF3R CSK CSNK2B CTDSP1 CTLA4 CTNND1 CTNND2 DAPP1 DEF6 DLG1 DOK1 DOK2 DOK3 EGFR ERBB2 ERBB3 ERBB4 ESR1 ESR2 EZR FAM166B FAM174A FAS FASLG FCGR3A FYN G3BP1 GAB1 GAB2 GATA3 GRAP HSP90AA1 IFNAR1 IKBKG IL2RB ITK JAK3 KHDRBS1 KIR2DL3 KIT LAT LAX1 LCP2 LIME1 LZTS2 MAPK1 MAPK3 MAPT MED28 MET MS4A1 MUC1 NEDD9 NFKBIA NFKBID NOTCH1 NR3C1 PAG1 PAK2 PECAM1 PI4KA PIK3CA PIK3R1 PLCG1 PLCG2 PLD2 PRKACA PRKCA PRKCD PRKCQ PTK2 PTK2B PTPN11 PTPN22 PTPN6 PTPRC PTPRF PTPRH PXN RAF1 RASA1 RIN3 RORB SH2B3 SH2D1A SH2D2A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SMAD2 SMAD3 SMURF1 SOS1 SQSTM1 STAT1 STAT3 STAT5A SYK THY1 TRAT1 TRIM35 TRPV4 TUB UBAP2 UBE3A UHRF2 UNC119 VAV1 WAS WASL ZAP70	193 interacting genes: ABL1 ABL2 ACYP1 AGTR2 ALDOA ATP5ME BCAR3 BEND5 BLK BLNK BTK CALM1 CD82 CDC25C CDK5 CFL1 CHN2 CRK CRKL CSPG5 DAB1 DAPP1 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 EGF EGFR EGR1 ENOPH1 ERBB2 ERBB4 ERG28 EYA4 EZR FAM241B FER FES FGFR1 FGR FHL3 FKBP1A FLNA FLYWCH1 GABARAPL1 GABARAPL2 GRAP2 GRB2 GRB7 HCK HDAC6 HINT1 HSH2D HSPA1A HSPA8 IL6ST ILKAP INPPL1 IRF2BP2 ITK JAK2 JAK3 JUP LAMTOR2 LBHD1 LCK LCP2 LRRC7 LYN MAP1B MATK MTMR1 MTMR10 MTMR2 MTMR6 MTMR8 MTMR9 MUC1 MUC4 MYCBP MYCBP2 NCK1 NCK2 NDUFAB1 NEDD4 NRG1 NRG2 NSMCE1 ODF2L PA2G4 PDGFRA PFDN2 PFDN4 PHPT1 PIK3R1 PIK3R2 PIK3R3 PIN4 PLCG1 PLCG2 PPM1A PPM1B PPM1F PPM1K PPM1M PRDX5 PRKACA PRRG4 PSMA5 PTEN PTGES3 PTK2 PTK2B PTK6 PTPDC1 PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRH PTPRR RALGAPA1 RASA1 RASA4 RGS4 RIN1 RNF41 RPN1 RTN4 RWDD2A S100A10 SAP18 SELENOK SF3B6 SH2B1 SH2B3 SH2D1A SH2D1B SH2D2A SH2D3A SH2D3C SH3BP2 SHB SHC1 SHC2 SHC3 SHC4 SHD SLA SLA2 SMIM20 SNAP91 SNRPB2 SOCS2 SOCS3 SOCS5 SOCS6 SOS1 SRC SRPK2 STAP1 STYX SYK SYNM TBCA TCEA2 TEC TMA7 TMEM134 TMEM14A TMEM230 TNS1 TNS2 TNS3 TNS4 TPTE TRIR TVP23B TXK TXN TXNL4A VAV1 VAV2 VAV3 VTA1 WRNIP1 YES1 YWHAZ ZAP70 ZNF207 ZNF532
Entrez ID		3932	2065
HPRD ID		01080	01820
Ensembl ID		ENSG00000182866	ENSG00000065361
Uniprot IDs		A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4	P21860
PDB IDs		1BHF 1BHH 1CWD 1CWE 1FBZ 1H92 1IJR 1KIK 1LCJ 1LCK 1LKK 1LKL 1Q68 1Q69 1QPC 1QPD 1QPE 1QPJ 1X27 2IIM 2OF2 2OF4 2OFU 2OFV 2OG8 2PL0 2ZM1 2ZM4 2ZYB 3AC1 3AC2 3AC3 3AC4 3AC5 3AC8 3ACJ 3ACK 3AD4 3AD5 3AD6 3B2W 3BRH 3BYM 3BYO 3BYS 3BYU 3KMM 3KXZ 3LCK 3MPM 4C3F 4D8K 5MTM 5MTN 6H6A 6PDJ	1M6B 2L9U 3KEX 3LMG 3P11 4LEO 4P59 4RIW 4RIX 4RIY 5CUS 5O4O 5O7P 6KBI 6OP9
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?