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GPR152 and HMOX1
Data Source:
BioGRID
(two hybrid)
GPR152
HMOX1
Description
G protein-coupled receptor 152
heme oxygenase 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Membrane
Extracellular Space
Nucleus
Nucleolus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Caveola
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
G Protein-coupled Receptor Activity
Protein Binding
Identical Protein Binding
Heme Oxygenase (decyclizing) Activity
Phospholipase D Activity
Structural Molecule Activity
Protein Binding
Enzyme Binding
Heme Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Biological Process
G Protein-coupled Receptor Signaling Pathway
Angiogenesis
Endothelial Cell Proliferation
Wound Healing Involved In Inflammatory Response
Negative Regulation Of Leukocyte Migration
Heme Oxidation
Cellular Iron Ion Homeostasis
Response To Oxidative Stress
Small GTPase Mediated Signal Transduction
Excretion
Regulation Of Blood Pressure
Cell Death
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Muscle Cell Apoptotic Process
Smooth Muscle Hyperplasia
Positive Regulation Of Macroautophagy
Negative Regulation Of Macroautophagy
Cytokine-mediated Signaling Pathway
Cellular Response To Nutrient
Positive Regulation Of Chemokine Production
Negative Regulation Of Mast Cell Cytokine Production
Erythrocyte Homeostasis
Low-density Lipoprotein Particle Clearance
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron
Cellular Response To Heat
Response To Nicotine
Intracellular Signal Transduction
Heme Catabolic Process
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Mast Cell Degranulation
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Response To Estrogen
Regulation Of Angiogenesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Smooth Muscle Cell Proliferation
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of DNA-binding Transcription Factor Activity
Iron Ion Homeostasis
Cellular Response To Arsenic-containing Substance
Cellular Response To Cadmium Ion
Cellular Response To Hypoxia
Cellular Response To Cisplatin
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Liver Regeneration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
Heme degradation
Interleukin-4 and Interleukin-13 signaling
Iron uptake and transport
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
NADH
Formic acid
Biliverdine IX Alpha
12-Phenylheme
2-Phenylheme
Verdoheme
Stannsoporfin
1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE
1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS
Non-response to citalopram or escitalopram and depression (
27622933
)
Refractive error (
32231278
)
Hippocampal volume in mild cognitive impairment (
29274321
)
Obesity-related traits (
23251661
)
Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease (
29748315
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
194 interacting genes:
-
ABCG4
ABHD16A
ACSF2
ADIPOQ
AGTRAP
AIG1
ANKRD46
APOL3
AQP10
AQP3
AQP6
ARL6IP1
ARV1
ATP6V0C
B3GNT7
BDNF
BET1
BMP10
BNIP2
BNIP3
C14orf180
C1QL4
C8A
CCDC167
CCL4
CCL4L2
CD53
CD72
CD81
CDIPT
CDS2
CGRRF1
CLDND2
CLEC17A
CLEC1A
CLN5
CNIH1
COL8A2
COMT
CRISP3
CSGALNACT2
CTXN3
CYB561
CYB561A3
CYB5B
CYB5R3
CYBC1
DEFB108B
DGAT2L6
EBP
EDDM3B
EFNA5
EMD
ERG28
FA2H
FAM20B
FAXDC2
FDFT1
FUNDC2
FXYD3
FXYD6-FXYD2
GAST
GJB2
GOLT1A
GOLT1B
GOSR2
GPR151
GPR37L1
HHATL
HMOX1
HMOX2
IFNA8
IGF2
IGFBP5
IL1RL1
INS-IGF2
INSIG2
JAGN1
KCNA1
KCNN4
LAMB1
LAT
LEPROTL1
LHFPL2
LHFPL5
LTC4S
MAL
MAL2
MFF
MFSD5
MFSD6
MGLL
MGST3
MMD
MOSPD3
MS4A13
MYADML2
NAT8
NDUFB11
NEU1
NINJ2
NIPAL4
ORMDL1
ORMDL3
PEDS1-UBE2V1
PEX16
PGAP2
PIGF
PIN1
PLN
PNLIPRP1
PRAF2
PROM2
PTPRN
RABAC1
RBFA
REEP6
ROBO2
RTN3
RTP2
SACM1L
SCAMP4
SCD
SEC22B
SERF1A
SERF1B
SERP2
SFT2D2
SFTPC
SLC10A1
SLC13A4
SLC29A2
SLC30A3
SLC35A4
SLC35B1
SLC35B4
SLC35C2
SLC35F6
SLC38A1
SLC38A7
SLC39A2
SLC41A1
SLC66A1
SLC66A2
SLC7A1
SMCO4
STATH
STX1B
STX3
STX4
STX5
STX8
SYT15
TAP1
TEX264
TFRC
THSD7B
TIMMDC1
TM4SF19
TMEM100
TMEM120B
TMEM128
TMEM140
TMEM14B
TMEM14C
TMEM201
TMEM208
TMEM218
TMEM236
TMEM237
TMEM243
TMEM254
TMEM42
TMEM50B
TMEM54
TMEM60
TMEM97
TMPPE
TNFRSF10C
TSNARE1
TSPAN33
TSPAN7
TSPO2
UBIAD1
UNC50
VAMP1
VAMP4
VAMP5
VKORC1
YIPF1
YIPF4
YIPF6
ZDHHC15
40 interacting genes:
AKT1
AQP6
ARL13B
ASL
BLVRB
CD79A
COQ9
CPLX4
CPSF1
CRB3
CREB3
CYB561
CYBRD1
ELOVL4
ELOVL5
ELOVL6
ERGIC3
FAM174A
FAM209A
FAM210B
GPR152
JAGN1
KASH5
LMNA
MSMO1
NOS1
PDZK1IP1
POR
POT1
PTGER4
SEC11C
SLC16A7
SMO
STX1A
TERF1
TLCD4
TM4SF19
TMEM14B
TMIE
TUT1
Entrez ID
390212
3162
HPRD ID
13599
00782
Ensembl ID
ENSG00000175514
ENSG00000100292
Uniprot IDs
A0A0I9RJ67
Q8TDT2
P09601
Q6FH11
PDB IDs
1N3U
1N45
1NI6
1OYK
1OYL
1OZE
1OZL
1OZR
1OZW
1S13
1S8C
1T5P
1TWN
1TWR
1XJZ
1XK0
1XK1
1XK2
1XK3
3CZY
3HOK
3K4F
3TGM
4WD4
5BTQ
6EHA
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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