NCAM1 and ST8SIA4

Data Source:
HPRD (in vitro)

		NCAM1	ST8SIA4
Description		neural cell adhesion molecule 1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
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GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Neuron Projection Collagen-containing Extracellular Matrix	Golgi Membrane Integral Component Of Membrane
	Molecular Function	Virus Receptor Activity Protein Binding	Alpha-N-acetylneuraminate Alpha-2,8-sialyltransferase Activity Sialic Acid Binding
	Biological Process	MAPK Cascade Cell Adhesion Axon Guidance Viral Entry Into Host Cell Interferon-gamma-mediated Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway	Ganglioside Biosynthetic Process Cellular Protein Modification Process Protein Glycosylation N-glycan Processing Nervous System Development Oligosaccharide Metabolic Process Sialylation
Pathways		ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling	Sialic acid metabolism NCAM1 interactions
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Cannabis use ( 30150663 27023175) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Heel bone mineral density ( 30598549 28869591) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878)	Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Response to radiotherapy in cancer (late toxicity) ( 24785509) Systemic lupus erythematosus ( 29848360 28714469) Waist circumference adjusted for body mass index ( 28552196) White blood cell count ( 32888494)
Interacting Genes		19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	1 interacting genes: NCAM1
Entrez ID		4684	7903
HPRD ID		00301	03970
Ensembl ID		ENSG00000149294	ENSG00000113532
Uniprot IDs		A0A087WWD4 P13591	Q92187
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	5Y22 5Y3U 6AHZ
Enriched GO Terms of Interacting Partners?
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