NCAM1 and RHEB

Data Source:
BioGRID (two hybrid)

		NCAM1	RHEB
Description		neural cell adhesion molecule 1	Ras homolog, mTORC1 binding
Image
GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Neuron Projection Collagen-containing Extracellular Matrix	Golgi Membrane Spliceosomal Complex Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	MAPK Cascade Cell Adhesion Axon Guidance Viral Entry Into Host Cell Interferon-gamma-mediated Signaling Pathway Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Cold-induced Thermogenesis Regulation Of Type B Pancreatic Cell Development
Pathways		ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Blood protein levels ( 30072576 29875488) Body mass index ( 25673413) Cannabis use ( 30150663 27023175) Cardiac muscle measurement ( 21212386) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Entorhinal cortical thickness ( 21116278) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Gut microbiota (bacterial taxa) ( 27694959) Heel bone mineral density ( 30598549 28869591) Macular thickness ( 30535121) Mood instability ( 31168069) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Pulse pressure ( 27841878) Risk-taking tendency (4-domain principal component model) ( 30643258) Sense of smell ( 26632684) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Smoking status (heavy vs never) ( 26423011) Suicide attempts in depression or bipolar disorder ( 24964207) Systolic blood pressure ( 27841878)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	29 interacting genes: A2M APOE APPBP2 ARIH2 ATM ATR BNIP3 BNIP3L BRAF CREB3 ECSIT FKBP8 HTT MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RNF152 RPS6KB1 RPTOR TRIM55 TRIM63 TSC1 TSC2 USP4
Entrez ID		4684	6009
HPRD ID		00301	03188
Ensembl ID		ENSG00000149294	ENSG00000106615
Uniprot IDs		A0A087WWD4 P13591	A0A090N900 Q15382
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	1XTQ 1XTR 1XTS 3SEA 3T5G 5YXH 6BCU 6BSX 6BT0 7BTA 7BTC 7BTD
Enriched GO Terms of Interacting Partners?
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