KRT85 and ALOX12

Data Source:
HPRD (two hybrid)

		KRT85	ALOX12
Description		keratin 85	arachidonate 12-lipoxygenase, 12S type
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Keratin Filament	Cytoplasm Cytosol Plasma Membrane Membrane Sarcolemma Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding	Arachidonate 12(S)-lipoxygenase Activity Iron Ion Binding Protein Binding Linoleate 13S-lipoxygenase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Hepoxilin-epoxide Hydrolase Activity Arachidonate 15-lipoxygenase Activity
	Biological Process	Epidermis Development Keratinization Cornification	Lipid Metabolic Process Aging Positive Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Arachidonic Acid Metabolic Process Lipoxygenase Pathway Fatty Acid Oxidation Unsaturated Fatty Acid Metabolic Process Lipid Oxidation Superoxide Anion Generation Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Linoleic Acid Metabolic Process Positive Regulation Of Smooth Muscle Cell Proliferation Hepoxilin Metabolic Process Hepoxilin Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Establishment Of Skin Barrier Cellular Response To Lipid Negative Regulation Of Platelet Aggregation Leukotriene A4 Metabolic Process Positive Regulation Of Endothelial Tube Morphogenesis Lipoxin Biosynthetic Process Lipoxin A4 Biosynthetic Process Lipoxin B4 Biosynthetic Process
Pathways		Keratinization Formation of the cornified envelope	Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins
Drugs
Diseases		Ectodermal dysplasia, pure hair-nail type (HNED)
GWAS		Body mass index ( 28552196)	Blood metabolite levels ( 24816252) Mean platelet volume ( 32888494)
Interacting Genes		26 interacting genes: ALOX12 CLIC3 CREB5 CYSRT1 GNE HAPLN2 KLHL38 KRT15 KRT16 KRT19 KRT25 KRT26 KRT27 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 LHX8 OTX1 TAB2 ZNF655	7 interacting genes: ITGB4 KAT5 KRT5 KRT85 LMNA PLA2G2A TRIB1
Entrez ID		3891	239
HPRD ID		04139	01066
Ensembl ID		ENSG00000135443	ENSG00000108839
Uniprot IDs		B7Z7N3 F5GYI5 P78386	P18054
PDB IDs			2ABU 3D3L
Enriched GO Terms of Interacting Partners?
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