RHOC and DIAPH1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RHOC	DIAPH1
Description		ras homolog family member C	diaphanous related formin 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cleavage Furrow Stereocilium Cell Projection Neuron Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Secretory Granule Membrane Ruffle Membrane Mitotic Spindle Ficolin-1-rich Granule Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Ion Channel Binding
	Biological Process	Mitotic Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Cell Migration Positive Regulation Of Cell Migration Cortical Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apical Junction Assembly Wound Healing, Spreading Of Cells Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Lipase Activity Skeletal Muscle Satellite Cell Migration	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Microtubule-based Process Protein Localization To Microtubule Neutrophil Degranulation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine Regulation Of Cell Motility
Pathways		Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins	RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical surface area (visual PC2) ( 32198502) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Mean platelet volume ( 32888494 27863252) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		8 interacting genes: ARHGAP1 CAV1 CIT DIAPH1 RIPOR2 RIPOR3 ROCK1 RTKN	17 interacting genes: APBB1 BAIAP2 CDC42 CDC7 CENPA GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		389	1729
HPRD ID		01322	03670
Ensembl ID		ENSG00000155366	ENSG00000131504
Uniprot IDs		A0A024R0C8 P08134	A0A2R8Y5N1 O60610 Q6URC4
PDB IDs		1Z2C 2GCN 2GCO 2GCP
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?