CCDC103 and RUVBL2

Data Source:
BioGRID (two hybrid)

		CCDC103	RUVBL2
Description		coiled-coil domain containing 103	RuvB like AAA ATPase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Axoneme Motile Cilium Outer Dynein Arm	Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Protein Binding ATP Binding Beta-catenin Binding ATPase Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity 5'-3' DNA Helicase Activity ADP Binding Unfolded Protein Binding ATPase Binding
	Biological Process	Heart Looping Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Outer Dynein Arm Assembly Inner Dynein Arm Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Axonemal Dynein Complex Assembly Determination Of Digestive Tract Left/right Asymmetry	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Folding Histone Acetylation DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways			Telomere Extension By Telomerase HATs acetylate histones
Drugs			Quercetin
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712)	Blood protein levels ( 28240269)
Interacting Genes		17 interacting genes: CENPN GRIPAP1 HGS MEOX1 MEOX2 PAX6 PICK1 PKN1 PLAAT1 PNMA6A PRKAR1B R3HCC1L RCN3 RUVBL2 SUOX USHBP1 VAC14	31 interacting genes: AGR2 APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 MYC NDRG1 RUVBL1 STOM TAF9 TBP TERT YWHAQ YY1
Entrez ID		388389	10856
HPRD ID		14200	16070
Ensembl ID		ENSG00000167131	ENSG00000183207
Uniprot IDs		Q8IW40	B3KNL2 Q9Y230
PDB IDs			2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9
Enriched GO Terms of Interacting Partners?
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