RUVBL2 and TAF9

Data Source:
BioGRID (pull down)

		RUVBL2	TAF9
Description		RuvB like AAA ATPase 2	TATA-box binding protein associated factor 9
Image
GO Annotations	Cellular Component	Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex	SAGA Complex PCAF Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex STAGA Complex Transcription Factor TFTC Complex Pre-snoRNP Complex MLL1 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Protein Binding ATP Binding Beta-catenin Binding ATPase Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity 5'-3' DNA Helicase Activity ADP Binding Unfolded Protein Binding ATPase Binding	Transcription Regulatory Region Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Activating Transcription Factor Binding Protein Heterodimerization Activity ATPase Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Folding Histone Acetylation DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomerase RNA Localization To Cajal Body	Box C/D SnoRNP Assembly Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process SnRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		Telomere Extension By Telomerase HATs acetylate histones	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs		Quercetin
Diseases
GWAS		Blood protein levels ( 28240269)
Interacting Genes		31 interacting genes: AGR2 APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 MYC NDRG1 RUVBL1 STOM TAF9 TBP TERT YWHAQ YY1	57 interacting genes: AHR ANK2 APP CEBPB CIITA COIL DRAP1 EEF1A1 ELF3 FBL FBLN1 FEZ1 GALNT6 GLI1 GLI2 GLI3 GTF2B H3-4 HCFC1 HNF4A HSF1 KLF6 KMT2A KPNA1 KPNA6 LAMTOR5 MAGEC2 MYC NCOA2 NCOR1 NDRG1 NFATC2 NR1D2 NUFIP1 PJA1 RBM48 RELA RNF138 RPS14 RPS24 RUVBL1 RUVBL2 SF3B3 TAF1 TAF10 TAF11 TAF12 TAF2 TAF4 TAF5 TAF6 TAF6L TAF7 TAF8 TBCA TP53 UBA1
Entrez ID		10856	6880
HPRD ID		16070	15983
Ensembl ID		ENSG00000183207	ENSG00000273841
Uniprot IDs		B3KNL2 Q9Y230	Q16594
PDB IDs		2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9	6F3T 6MZC 6MZD 6MZL 6MZM
Enriched GO Terms of Interacting Partners?
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