RUVBL2 and CCDC103

Data Source:
BioGRID (two hybrid)

		RUVBL2	CCDC103
Description		RuvB like AAA ATPase 2	coiled-coil domain containing 103
Image			No pdb structure
GO Annotations	Cellular Component	Euchromatin Swr1 Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex	Extracellular Region Cytoplasm Axoneme Motile Cilium Outer Dynein Arm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Protein Binding ATP Binding Beta-catenin Binding ATPase Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity 5'-3' DNA Helicase Activity ADP Binding Unfolded Protein Binding ATPase Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Folding Histone Acetylation DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomerase RNA Localization To Cajal Body	Heart Looping Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Outer Dynein Arm Assembly Inner Dynein Arm Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Axonemal Dynein Complex Assembly Determination Of Digestive Tract Left/right Asymmetry
Pathways		Telomere Extension By Telomerase HATs acetylate histones
Drugs		Quercetin
Diseases
GWAS		Blood protein levels ( 28240269)	Asthma ( 31619474) Craniofacial microsomia ( 26853712)
Interacting Genes		31 interacting genes: AGR2 APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DNAJB4 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 MYC NDRG1 RUVBL1 STOM TAF9 TBP TERT YWHAQ YY1	17 interacting genes: CENPN GRIPAP1 HGS MEOX1 MEOX2 PAX6 PICK1 PKN1 PLAAT1 PNMA6A PRKAR1B R3HCC1L RCN3 RUVBL2 SUOX USHBP1 VAC14
Entrez ID		10856	388389
HPRD ID		16070	14200
Ensembl ID		ENSG00000183207	ENSG00000167131
Uniprot IDs		B3KNL2 Q9Y230	Q8IW40
PDB IDs		2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6K0R 6QI8 6QI9
Enriched GO Terms of Interacting Partners?
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