CCDC103 and CENPN

Data Source:
BioGRID (two hybrid)

		CCDC103	CENPN
Description		coiled-coil domain containing 103	centromere protein N
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Axoneme Motile Cilium Outer Dynein Arm	Condensed Chromosome Kinetochore Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein Homodimerization Activity
	Biological Process	Heart Looping Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Determination Of Left/right Symmetry Outer Dynein Arm Assembly Inner Dynein Arm Assembly Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Axonemal Dynein Complex Assembly Determination Of Digestive Tract Left/right Asymmetry	Chromosome Segregation CENP-A Containing Nucleosome Assembly Kinetochore Assembly
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: CENPN GRIPAP1 HGS MEOX1 MEOX2 PAX6 PICK1 PKN1 PLAAT1 PNMA6A PRKAR1B R3HCC1L RCN3 RUVBL2 SUOX USHBP1 VAC14	4 interacting genes: ALKBH7 CCDC103 OSGIN1 TSSK3
Entrez ID		388389	55839
HPRD ID		14200	12528
Ensembl ID		ENSG00000167131	ENSG00000166451
Uniprot IDs		Q8IW40	Q96H22
PDB IDs			6BUZ 6C0W 6EQT 6MUO 6MUP
Enriched GO Terms of Interacting Partners?
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