KRTAP5-3 and NR4A3

Data Source:
BioGRID (two hybrid)

		KRTAP5-3	NR4A3
Description		keratin associated protein 5-3	nuclear receptor subfamily 4 group A member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity
	Biological Process	Keratinization	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Gastrulation Pyruvate Oxidation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glucose Transmembrane Transport Intracellular Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Mast Cell Cytokine Production Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Mast Cell Degranulation Steroid Hormone Mediated Signaling Pathway Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Positive Regulation Of Monocyte Aggregation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior
Pathways		Keratinization	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Beta-D-Glucose	Dasatinib
Diseases			Extraskeletal myxoid chondrosarcoma
GWAS			Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424)
Interacting Genes		43 interacting genes: ADAMTSL4 CATSPER1 CRCT1 CYSRT1 ECM1 FBXO34 FUCA2 GLRX3 HOXA1 KPRP KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP11-1 KRTAP15-1 KRTAP4-2 KRTAP5-1 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2C LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NOTCH2NLA NR4A3 NUFIP2 OTX1 POU4F2 RAMP3 RGS17 SMCP	43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330
Entrez ID		387266	8013
HPRD ID		12395	02766
Ensembl ID		ENSG00000196224	ENSG00000119508
Uniprot IDs		Q6L8H2	A0A024R168 Q92570
PDB IDs
Enriched GO Terms of Interacting Partners?
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