RHOA and TGFBR1

Data Source:
HPRD (in vivo)

		RHOA	TGFBR1
Description		ras homolog family member A	transforming growth factor beta receptor 1
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GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Cell Junction Midbody Secretory Granule Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Vesicle Cleavage Furrow Cell Projection Dendritic Spine Intracellular Membrane-bounded Organelle Apical Junction Complex Extracellular Exosome Cell Periphery Postsynapse Glutamatergic Synapse Ficolin-1-rich Granule Membrane	Nucleus Endosome Plasma Membrane Bicellular Tight Junction Cell Surface Receptor Complex Membrane Raft Activin Receptor Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Myosin Binding Protein Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Activin Receptor Activity, Type I Growth Factor Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding I-SMAD Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Cell Shape Negative Regulation Of Cell-substrate Adhesion Viral Process Cell Migration Protein Deubiquitination Substantia Nigra Development Actin Cytoskeleton Organization Regulation Of Cell Migration Cortical Cytoskeleton Organization Cytoplasmic Microtubule Organization Actin Cytoskeleton Reorganization Positive Regulation Of Cytokinesis Regulation Of Actin Cytoskeleton Organization Regulation Of Osteoblast Proliferation Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Roundabout Signaling Pathway Cleavage Furrow Formation Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Stress Fiber Assembly Apical Junction Assembly Neutrophil Degranulation Endothelial Cell Migration Ossification Involved In Bone Maturation Wound Healing, Spreading Of Cells Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Neuron Differentiation Negative Regulation Of Cell Size Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Negative Chemotaxis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lipase Activity Trabecula Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mitotic Spindle Assembly Endothelial Tube Lumen Extension Positive Regulation Of NIK/NF-kappaB Signaling Skeletal Muscle Satellite Cell Migration Mitotic Cleavage Furrow Formation Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Cellular Response To Chemokine Regulation Of Cell Motility Positive Regulation Of T Cell Migration	Activation Of MAPKK Activity Skeletal System Development In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Proepicardium Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Arrest Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Deubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Collagen Fibril Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Wound Healing Endothelial Cell Activation Extracellular Structure Organization Regulation Of Protein Binding Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Roof Of Mouth Development Pharyngeal System Development Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Response To Cholesterol Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Epicardium Morphogenesis Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		GPVI-mediated activation cascade Axonal growth inhibition (RHOA activation) Rho GTPase cycle PI3K/AKT activation Axonal growth stimulation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) G beta:gamma signalling through PI3Kgamma EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse PCP/CE pathway G alpha (12/13) signalling events Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases activate KTN1 RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins Ovarian tumor domain proteases ERBB2 Regulates Cell Motility Neutrophil degranulation PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases SLIT2:ROBO1 increases RHOA activity	Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases Ub-specific processing proteases
Drugs		Guanosine-5'-Diphosphate	4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline Naphthyridine Inhibitor 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine Fostamatinib
Diseases			Loeys-Dietz syndrome (LDS) Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Gut microbiota (functional units) ( 27694959) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Morning person ( 30696823) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636) Asthma ( 31959851 32296059) Callous-unemotional behaviour ( 23874384) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23064961) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gestational age at birth (maternal effect) ( 28877031) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		124 interacting genes: AGAP1 AGAP2 AKAP13 ANKS1B ARAP2 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP19 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP26 ARHGAP29 ARHGAP31 ARHGAP32 ARHGAP40 ARHGAP5 ARHGAP8 ARHGDIA ARHGDIB ARHGDIG ARHGEF1 ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF28 ARHGEF3 ARHGEF4 ARHGEF5 ARNTL BCR BIRC2 CAV1 CIT CLOCK CNKSR1 CNTNAP1 DAAM1 DCUN1D1 DEF6 DGKQ DIAPH1 DIAPH3 DLC1 DOCK7 DVL2 FLNA FMN2 GMIP HSPA1A ICMT IKBKG IKZF3 ITPR1 KCNA2 KCTD13 KTN1 LRP2 MCF2 MCF2L MPRIP MYO9A NET1 NGEF NOTCH1 OPHN1 OTUB1 PDE6D PITPNM1 PKN1 PKN2 PLCG1 PLD1 PLEKHG2 PLEKHG4 PLEKHG6 PPP1R12A PREX1 PREX2 PRKACA PRKCA PRKCZ PTPRF RABAC1 RACK1 RAP1GDS1 RASGRF1 RASGRF2 RASSF1 RHPN1 RHPN2 RIPK4 RIPOR2 RIPOR3 ROCK1 RPN2 RTKN SH3BP1 SLC13A1 SMAD2 SMURF1 SMURF2 SPRED2 SRGAP1 STARD8 TGFBR1 TGM2 TIAM1 TNFAIP1 TRIO TRIP6 TRPC1 VAV1 VAV2 VAV3	163 interacting genes: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13 EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FKBP1B FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 MAP3K20 MAP3K7 MYO3A MYOC MYT1L NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OTUB1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 PSMD14 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP2 USP45 VEPH1 WDR13 WDR33 WDR61 XIAP ZFYVE9
Entrez ID		387	7046
HPRD ID		01323	01822
Ensembl ID		ENSG00000067560	ENSG00000106799
Uniprot IDs		A0A024R324 B4DKN9 C9JRM1 C9JX21 P61586 Q9BVT0	B4DXN7 B4DY26 P36897 Q5T7S2
PDB IDs		1A2B 1CC0 1CXZ 1DPF 1FTN 1KMQ 1LB1 1OW3 1S1C 1TX4 1X86 1XCG 2RGN 3KZ1 3LW8 3LWN 3LXR 3MSX 3T06 4D0N 4XH9 4XOI 4XSG 4XSH 5A0F 5BWM 5C2K 5C4M 5EZ6 5FR1 5FR2 5HPY 5IRC 5JCP 5JHG 5JHH 5M6X 5M70 5ZHX 6BC0 6BCA 6BCB 6KX2 6KX3 6R3V	1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM 4X0M 4X2F 4X2G 4X2J 4X2K 4X2N 5E8S 5E8T 5E8U 5E8W 5E8X 5E8Z 5E90 5FRI 5QIK 5QIL 5QIM 5QTZ 5QU0 5USQ 6B8Y 6MAC
Enriched GO Terms of Interacting Partners?
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