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TGFBR1 and CUL5
Data Source:
HPRD
(in vivo)
TGFBR1
CUL5
Description
transforming growth factor beta receptor 1
cullin 5
Image
GO Annotations
Cellular Component
Nucleus
Endosome
Plasma Membrane
Bicellular Tight Junction
Cell Surface
Receptor Complex
Membrane Raft
Activin Receptor Complex
Cytosol
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Site Of DNA Damage
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Growth Factor Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
I-SMAD Binding
Ubiquitin-protein Transferase Activity
Calcium Channel Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Biological Process
Activation Of MAPKK Activity
Skeletal System Development
In Utero Embryonic Development
Kidney Development
Blastocyst Development
Epithelial To Mesenchymal Transition
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Proepicardium Development
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Apoptotic Process
Cell Cycle Arrest
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Male Gonad Development
Post-embryonic Development
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Intracellular Signal Transduction
Wound Healing
Endothelial Cell Activation
Extracellular Structure Organization
Regulation Of Protein Binding
Endothelial Cell Migration
Positive Regulation Of Transcription, DNA-templated
Thymus Development
Neuron Fate Commitment
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Mesenchymal Cell Differentiation
Artery Morphogenesis
Cell Motility
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Parathyroid Gland Development
Roof Of Mouth Development
Pharyngeal System Development
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Epithelial To Mesenchymal Transition
Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Angiogenesis Involved In Coronary Vascular Morphogenesis
Coronary Artery Morphogenesis
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Tight Junction Disassembly
Epicardium Morphogenesis
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Viral Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
ERBB2 Signaling Pathway
Post-translational Protein Modification
Calcium Ion Transmembrane Transport
Intrinsic Apoptotic Signaling Pathway
Pathways
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
Ub-specific processing proteases
Vif-mediated degradation of APOBEC3G
Downregulation of ERBB2 signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
Naphthyridine Inhibitor
3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
Fostamatinib
Diseases
Loeys-Dietz syndrome (LDS)
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
23455636
)
Asthma (
31959851
32296059
)
Callous-unemotional behaviour (
23874384
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Dental caries (
23064961
)
Epithelial ovarian cancer (
25134534
)
Fractures (paediatric) (
32742401
)
Gestational age at birth (maternal effect) (
28877031
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Refractive error (
32231278
)
Interacting Genes
163 interacting genes:
ACVR1
ACVRL1
AMHR2
ANAPC5
AP2B1
ARHGAP15
ARHGAP31
ARHGEF6
ARL4D
ARL8B
ASH2L
AURKB
BAMBI
BMPR1B
BMPR2
BTBD2
CAV1
CD44
CDC20
CDC42EP4
CDK14
CDK17
CDK4
CDK6
CDKL1
CHN1
CHN2
CHUK
CLU
CSNK1A1
CSNK2A2
CTNNB1
CUL5
DAB2
DAPK2
DCAF12
DCAF6
DUSP13
EIF2AK4
ENC1
ENG
FANCL
FBXL12
FBXO34
FKBP1A
FKBP1B
FNTA
GNA13
GNB2
GNB3
IKBKB
ITK
KATNB1
KCNK18
KLHL1
KLHL35
LIMS1
MAP3K20
MAP3K7
MYO3A
MYOC
MYT1L
NAT8
NEK6
NEK8
NKIRAS1
NRP1
NUAK2
NUP37
OSR1
OTUB1
OXSR1
PAK1
PARD6A
PIK3R1
PIK3R2
PLEK
PLEKHB1
PLEKHJ1
PLK4
PML
POMK
PPP2R2A
PPP3CC
PPP6C
PREB
PREX2
PRPF4
PSMD14
RAB13
RAB25
RAB33B
RAB34
RAB38
RAB3B
RAB6B
RAN
RAP2A
RASD2
RASL12
RGS19
RHEBL1
RHOA
RHOD
RHOG
RHOH
RHOJ
RHPN2
RNF130
RNF146
RNF5
RPAP3
RPS27A
RRH
RTKN
SAMD8
SAT2
SKAP2
SKI
SMAD1
SMAD2
SMAD3
SMAD4
SMAD6
SMAD7
SMURF2
SNTG1
SNX6
SOCS6
SQSTM1
STK35
STRAP
STUB1
STX8
STYXL1
TGFB1
TGFB2
TGFB3
TGFBR2
TGFBRAP1
TNNT1
TRAF6
TRAP1
TSC22D1
TSSK1B
TSSK4
TTC1
TTC27
TTPAL
UBA52
UBB
UBD
UBE2E3
UBE2Z
UBXN1
USP2
USP45
VEPH1
WDR13
WDR33
WDR61
XIAP
ZFYVE9
36 interacting genes:
ANAPC11
ASB11
CCNB1IP1
CCNDBP1
COG6
COMMD1
COPS2
COPS3
COPS4
COPS5
COPS6
COPS7A
COPS8
DCUN1D1
DEPTOR
ELOA
ERCC6
GHR
GOLGA2
GPS1
KANK4
PRKACA
PTPN5
RBX1
RHOBTB1
RHOBTB2
RHOU
RNF7
SMAD2
SMURF1
SOX30
TGFBR1
TRAF6
UBC
UBE2F
VHL
Entrez ID
7046
8065
HPRD ID
01822
03444
Ensembl ID
ENSG00000106799
ENSG00000166266
Uniprot IDs
B4DXN7
B4DY26
P36897
Q5T7S2
Q93034
PDB IDs
1B6C
1IAS
1PY5
1RW8
1TBI
1VJY
2L5S
2PJY
2WOT
2WOU
2X7O
3FAA
3GXL
3HMM
3KCF
3KFD
3TZM
4X0M
4X2F
4X2G
4X2J
4X2K
4X2N
5E8S
5E8T
5E8U
5E8W
5E8X
5E8Z
5E90
5FRI
5QIK
5QIL
5QIM
5QTZ
5QU0
5USQ
6B8Y
6MAC
3DPL
3DQV
4JGH
4N9F
6V9I
Enriched GO Terms of Interacting Partners
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