TGFBR1 and RAN

Data Source:
HPRD (in vivo)

		TGFBR1	RAN
Description		transforming growth factor beta receptor 1	RAN, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Endosome Plasma Membrane Bicellular Tight Junction Cell Surface Receptor Complex Membrane Raft Activin Receptor Complex	Chromatin Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Centriole Cytosol Membrane Midbody Protein-containing Complex Melanosome RNA Nuclear Export Complex Host Cell Recycling Endosome Extracellular Exosome Flemming Body
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding Activin Receptor Activity, Type I Growth Factor Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding I-SMAD Binding	Magnesium Ion Binding Chromatin Binding RNA Binding GTPase Activity Nuclear Export Signal Receptor Activity Protein Binding GTP Binding GDP Binding Cadherin Binding Protein Heterodimerization Activity Pre-miRNA Binding
	Biological Process	Activation Of MAPKK Activity Skeletal System Development In Utero Embryonic Development Kidney Development Blastocyst Development Epithelial To Mesenchymal Transition Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lens Development In Camera-type Eye Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Proepicardium Development Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cell Cycle Arrest Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Heart Development Positive Regulation Of Cell Population Proliferation Germ Cell Migration Male Gonad Development Post-embryonic Development Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Deubiquitination Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Collagen Fibril Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Intracellular Signal Transduction Wound Healing Endothelial Cell Activation Extracellular Structure Organization Regulation Of Protein Binding Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Thymus Development Neuron Fate Commitment Embryonic Cranial Skeleton Morphogenesis Skeletal System Morphogenesis Mesenchymal Cell Differentiation Artery Morphogenesis Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Parathyroid Gland Development Roof Of Mouth Development Pharyngeal System Development Regulation Of Cardiac Muscle Cell Proliferation Cardiac Epithelial To Mesenchymal Transition Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Response To Cholesterol Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly Epicardium Morphogenesis Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Mitotic Sister Chromatid Segregation Mitotic Cell Cycle DNA Metabolic Process TRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization MiRNA Metabolic Process Viral Process Positive Regulation Of Protein Binding Pre-miRNA Export From Nucleus Positive Regulation Of Protein Import Into Nucleus Regulation Of Cholesterol Biosynthetic Process GTP Metabolic Process Cell Division SnRNA Import Into Nucleus Intracellular Transport Of Virus Protein Localization To Nucleolus
Pathways		Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer UCH proteinases Ub-specific processing proteases	Rev-mediated nuclear export of HIV RNA Regulation of cholesterol biosynthesis by SREBP (SREBF) NEP/NS2 Interacts with the Cellular Export Machinery Nuclear import of Rev protein MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs tRNA processing in the nucleus Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
Drugs		4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline Naphthyridine Inhibitor 3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide 2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine Fostamatinib	Guanosine-5'-Diphosphate
Diseases		Loeys-Dietz syndrome (LDS) Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23455636) Asthma ( 31959851 32296059) Callous-unemotional behaviour ( 23874384) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903) Dental caries ( 23064961) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gestational age at birth (maternal effect) ( 28877031) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		163 interacting genes: ACVR1 ACVRL1 AMHR2 ANAPC5 AP2B1 ARHGAP15 ARHGAP31 ARHGEF6 ARL4D ARL8B ASH2L AURKB BAMBI BMPR1B BMPR2 BTBD2 CAV1 CD44 CDC20 CDC42EP4 CDK14 CDK17 CDK4 CDK6 CDKL1 CHN1 CHN2 CHUK CLU CSNK1A1 CSNK2A2 CTNNB1 CUL5 DAB2 DAPK2 DCAF12 DCAF6 DUSP13 EIF2AK4 ENC1 ENG FANCL FBXL12 FBXO34 FKBP1A FKBP1B FNTA GNA13 GNB2 GNB3 IKBKB ITK KATNB1 KCNK18 KLHL1 KLHL35 LIMS1 MAP3K20 MAP3K7 MYO3A MYOC MYT1L NAT8 NEK6 NEK8 NKIRAS1 NRP1 NUAK2 NUP37 OSR1 OTUB1 OXSR1 PAK1 PARD6A PIK3R1 PIK3R2 PLEK PLEKHB1 PLEKHJ1 PLK4 PML POMK PPP2R2A PPP3CC PPP6C PREB PREX2 PRPF4 PSMD14 RAB13 RAB25 RAB33B RAB34 RAB38 RAB3B RAB6B RAN RAP2A RASD2 RASL12 RGS19 RHEBL1 RHOA RHOD RHOG RHOH RHOJ RHPN2 RNF130 RNF146 RNF5 RPAP3 RPS27A RRH RTKN SAMD8 SAT2 SKAP2 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMAD6 SMAD7 SMURF2 SNTG1 SNX6 SOCS6 SQSTM1 STK35 STRAP STUB1 STX8 STYXL1 TGFB1 TGFB2 TGFB3 TGFBR2 TGFBRAP1 TNNT1 TRAF6 TRAP1 TSC22D1 TSSK1B TSSK4 TTC1 TTC27 TTPAL UBA52 UBB UBD UBE2E3 UBE2Z UBXN1 USP2 USP45 VEPH1 WDR13 WDR33 WDR61 XIAP ZFYVE9	58 interacting genes: ABL1 ADRB2 AR ASAP2 BCAR1 BIRC5 BMPR1B CEP126 CSE1L DUX4 EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUTF2 NXF1 NXT1 PAK4 PARP10 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 SUMO2 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		7046	5901
HPRD ID		01822	03109
Ensembl ID		ENSG00000106799	ENSG00000132341
Uniprot IDs		B4DXN7 B4DY26 P36897 Q5T7S2	B4DV51 P62826
PDB IDs		1B6C 1IAS 1PY5 1RW8 1TBI 1VJY 2L5S 2PJY 2WOT 2WOU 2X7O 3FAA 3GXL 3HMM 3KCF 3KFD 3TZM 4X0M 4X2F 4X2G 4X2J 4X2K 4X2N 5E8S 5E8T 5E8U 5E8W 5E8X 5E8Z 5E90 5FRI 5QIK 5QIL 5QIM 5QTZ 5QU0 5USQ 6B8Y 6MAC	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 2MMC 2MMG 2N1B 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4C0Q 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4 4OL0 4WVF 5CIQ 5CIT 5CIW 5CJ2 5CLL 5CLQ 5DH9 5DHA 5DHF 5DI9 5DIF 5DIS 5DLQ 5FYQ 5JLJ 5UWH 5UWI 5UWJ 5UWO 5UWP 5UWQ 5UWR 5UWS 5UWT 5UWU 5UWW 5YRO 5YST 5YSU 5YTB 5ZPU 6A38 6A3A 6A3B 6A3C 6A3E 6CIT 6KFT 6Q82 6Q84 6TVO 6X2M 6X2O 6X2P 6X2R 6X2S 6X2U 6X2V 6X2W 6X2X 6X2Y
Enriched GO Terms of Interacting Partners?
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