PUS10 and KRT14

Data Source:
BioGRID (two hybrid)

		PUS10	KRT14
Description		pseudouridine synthase 10	keratin 14
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Pseudouridine Synthase Activity Metal Ion Binding Primary MiRNA Binding TRNA Pseudouridine Synthase Activity	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding
	Biological Process	Primary MiRNA Processing TRNA Pseudouridine Synthesis	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Keratinization Hemidesmosome Assembly Hair Cycle Intermediate Filament Bundle Assembly Cornification
Pathways			Type I hemidesmosome assembly Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases			Naegeli-Franceschetti-Jadassohn syndrome Dermatopathia pigmentosa reticularis Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Atopic dermatitis ( 26482879) Celiac disease ( 22057235 25920553 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22412388) Crohn's disease and celiac disease ( 21298027) Erectile dysfunction ( 30583798) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244) Ulcerative colitis ( 28067908 20228799 21297633)
Interacting Genes		5 interacting genes: ABITRAM KRT14 KRT16 NECAB2 USP25	32 interacting genes: ABI2 ABI3 AMOT APC BFSP2 CTTNBP2 DST ENKD1 GAS8 HGS HSPA5 KIFC3 KRT1 KRT3 KRT5 KRT6C KRT72 KRT78 KRT79 KRT80 KRT81 KRT86 OIP5 PKP1 PRPH PUS10 SDCBP SMARCE1 TCHP TRADD UBASH3A USHBP1
Entrez ID		150962	3861
HPRD ID		08126	01017
Ensembl ID		ENSG00000162927	ENSG00000186847
Uniprot IDs		A8K6R4 Q3MIT2	P02533
PDB IDs		2V9K	3TNU 6JFV
Enriched GO Terms of Interacting Partners?
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