KRT8 and KRT36

Data Source:
BioGRID (two hybrid)

		KRT8	KRT36
Description		keratin 8	keratin 36
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cell-cell Junction Dystrophin-associated Glycoprotein Complex Apicolateral Plasma Membrane Nuclear Matrix Z Disc Sarcolemma Costamere Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome	Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Protein Binding Protein-containing Complex Binding Scaffold Protein Binding	Structural Constituent Of Skin Epidermis
	Biological Process	Viral Process Keratinization Tumor Necrosis Factor-mediated Signaling Pathway Sarcomere Organization Response To Hydrostatic Pressure Response To Other Organism Cell Differentiation Involved In Embryonic Placenta Development Cornification Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process	Biological_process Keratinization Regulation Of Keratinocyte Differentiation Cornification
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs		Tenecteplase Lanoteplase Copper
Diseases
GWAS		Cancer (pleiotropy) ( 27197191) Gamma glutamyl transferase levels ( 29403010) Mean reticulocyte volume ( 32888494) Prostate cancer ( 21743057)
Interacting Genes		49 interacting genes: ANXA1 BYSL CEP57 CLK1 DEDD DMD EGFR ESR1 FBXO25 FGFR3 GRB2 HSPA5 IKBKG KPNA2 KRT13 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT38 KRT40 LINC01554 MAPK1 MAPK14 MAPK3 MAPK8 NEK6 PKD1 PKP1 PLAT PNN PPL QRSL1 RAF1 SUMO2 TCHP TFIP11 TRIM54 TROAP WBP2	52 interacting genes: ABI2 ABI3 AIMP2 AMOT APP BCAS2 C1orf216 CCBE1 CCHCR1 CDC23 DMRT3 EXOC8 GEM GPS2 HCK HGS HOXC8 KRT1 KRT2 KRT3 KRT4 KRT6A KRT6C KRT73 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT85 KRT86 MAP3K1 MYOZ1 MYOZ3 PKN1 PLEKHN1 PPP1R18 PSMB1 QARS1 RESF1 RIBC1 SMURF1 TMSB4X TRAF4 TSGA10IP TTC23 TTLL10 TXLNA ZNF414 ZNF785
Entrez ID		3856	8689
HPRD ID		01015	05174
Ensembl ID		ENSG00000170421	ENSG00000126337
Uniprot IDs		P05787 Q7L4M3	O76013
PDB IDs
Enriched GO Terms of Interacting Partners?
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