MIA3 and HSD17B14

Data Source:
BioGRID (two hybrid)

		MIA3	HSD17B14
Description		MIA SH3 domain ER export factor 3	hydroxysteroid 17-beta dehydrogenase 14
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Endoplasmic Reticulum Exit Site	Cytosol
	Molecular Function	Protein Binding Cargo Receptor Activity	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Leukocyte Migration Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endocytosis Endoplasmic Reticulum Organization Negative Regulation Of Cell Adhesion Protein Secretion Protein Transport Negative Regulation Of Cell Migration Vesicle Cargo Loading Wound Healing Lipoprotein Transport Post-translational Protein Modification Cellular Protein Metabolic Process Protein Localization To Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Migration	Estrogen Biosynthetic Process Steroid Catabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation	Estrogen biosynthesis
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254 29212778 30104761 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449 21378990) Myocardial infarction ( 26343387) Myocardial infarction (early onset) ( 19198609)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		16 interacting genes: CACNA1A CEP55 CLIC3 COL7A1 FXR2 HOMER3 HSD17B14 ITGAX LENG8 MTNR1B NCK2 PRDM14 SEC16A SEC23A SEC24C TRIM27	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		375056	51171
HPRD ID		18918	16801
Ensembl ID		ENSG00000154305	ENSG00000087076
Uniprot IDs		Q5JRA6	A0A140VJH8 Q9BPX1
PDB IDs		5KYN 5KYU 5KYW	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK
Enriched GO Terms of Interacting Partners?
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