NDUFS7 and MT-ND1

Data Source:
HPRD (in vitro)

		NDUFS7	MT-ND1
Description		NADH:ubiquinone oxidoreductase core subunit S7	NADH dehydrogenase subunit 1
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GO Annotations	Cellular Component	Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Integral Component Of Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Metal Ion Binding Quinone Binding 4 Iron, 4 Sulfur Cluster Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Electron Transport Coupled Proton Transport Mitochondrial Respiratory Chain Complex I Assembly	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Response To Organic Cyclic Compound Mitochondrial Respiratory Chain Complex I Assembly Response To Hydroperoxide Response To Drug
Pathways		Respiratory electron transport Complex I biogenesis	Respiratory electron transport Complex I biogenesis
Drugs		NADH	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS
Interacting Genes		3 interacting genes: ARRB2 ENO2 MT-ND1	12 interacting genes: BARD1 BRCA1 DHDDS FAT1 LIG4 MEOX2 NDUFS7 PAXIP1 RPL13A RPL6 SIRPA TST
Entrez ID		374291	4535
HPRD ID		03491	08365
Ensembl ID		ENSG00000115286	ENSG00000198888
Uniprot IDs		O75251 Q6ZS38 Q7LD69	P03886 U5Z754
PDB IDs		5XTB 5XTD 5XTH 5XTI	5XTC 5XTD
Enriched GO Terms of Interacting Partners?
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