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MAPK1 and HIF1A
Data Source:
BioGRID
(enzymatic study)
MAPK1
HIF1A
Description
mitogen-activated protein kinase 1
hypoxia inducible factor 1 subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Early Endosome
Late Endosome
Golgi Apparatus
Microtubule Organizing Center
Cytosol
Cytoskeleton
Plasma Membrane
Caveola
Focal Adhesion
Postsynaptic Density
Axon
Pseudopodium
Dendrite Cytoplasm
Protein-containing Complex
Azurophil Granule Lumen
Perikaryon
Mitotic Spindle
Ficolin-1-rich Granule Lumen
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Nuclear Body
Nuclear Speck
Motile Cilium
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Axon Cytoplasm
Molecular Function
Phosphotyrosine Residue Binding
Double-stranded DNA Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Kinase Activity
Phosphatase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Identical Protein Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Kinase Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Histone Acetyltransferase Binding
Nuclear Hormone Receptor Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Hsp90 Protein Binding
E-box Binding
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Activation Of MAPK Activity
Protein Phosphorylation
Apoptotic Process
Chemotaxis
Cellular Response To DNA Damage Stimulus
Cell Cycle
Signal Transduction
Cell Surface Receptor Signaling Pathway
Chemical Synaptic Transmission
Axon Guidance
Aging
Learning Or Memory
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Phosphatidylinositol 3-kinase Signaling
Diadenosine Tetraphosphate Biosynthetic Process
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sensory Perception Of Pain
Cytosine Metabolic Process
Platelet Activation
Regulation Of Ossification
Regulation Of Cellular PH
Thyroid Gland Development
Regulation Of Protein Stability
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Telomere Maintenance Via Telomerase
Regulation Of Stress-activated MAPK Cascade
Mammary Gland Epithelial Cell Proliferation
Cellular Response To Amino Acid Starvation
Cellular Response To Reactive Oxygen Species
Response To Nicotine
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB Signaling Pathway
Positive Regulation Of Protein Import Into Nucleus
Outer Ear Morphogenesis
Neutrophil Degranulation
Response To Exogenous DsRNA
Response To Estrogen
Negative Regulation Of Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Decidualization
Thymus Development
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Stress-activated MAPK Cascade
Regulation Of Cytoskeleton Organization
Positive Regulation Of Telomerase Activity
Bergmann Glial Cell Differentiation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Long-term Synaptic Potentiation
Face Development
Lung Morphogenesis
Trachea Formation
Labyrinthine Layer Blood Vessel Development
Cardiac Neural Crest Cell Development Involved In Heart Development
ERK1 And ERK2 Cascade
Response To Epidermal Growth Factor
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Caveolin-mediated Endocytosis
Regulation Of Golgi Inheritance
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Macrophage Proliferation
Regulation Of Cellular Response To Heat
Cellular Response To Dopamine
Positive Regulation Of Telomere Capping
Regulation Of Early Endosome To Late Endosome Transport
Response To Reactive Oxygen Species
Angiogenesis
Response To Hypoxia
Neural Crest Cell Migration
Epithelial To Mesenchymal Transition
Embryonic Placenta Development
B-1 B Cell Homeostasis
Positive Regulation Of Endothelial Cell Proliferation
Heart Looping
Positive Regulation Of Neuroblast Proliferation
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Cytokine Production Involved In Inflammatory Response
Outflow Tract Morphogenesis
Cardiac Ventricle Morphogenesis
Lactate Metabolic Process
Regulation Of Glycolytic Process
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cellular Iron Ion Homeostasis
Signal Transduction
Lactation
Visual Learning
Response To Iron Ion
Regulation Of Gene Expression
Vascular Endothelial Growth Factor Production
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Response To Muscle Activity
Positive Regulation Of Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Cytokine-mediated Signaling Pathway
Axonal Transport Of Mitochondrion
Neural Fold Elevation Formation
Cerebral Cortex Development
Negative Regulation Of Bone Mineralization
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of TOR Signaling
Oxygen Homeostasis
Positive Regulation Of Chemokine Production
Regulation Of Transforming Growth Factor Beta2 Production
Collagen Metabolic Process
Embryonic Hemopoiesis
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Hemoglobin Biosynthetic Process
Glucose Homeostasis
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Post-translational Protein Modification
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Growth
Positive Regulation Of Transcription By RNA Polymerase II
Muscle Cell Cellular Homeostasis
Positive Regulation Of Hormone Biosynthetic Process
Digestive Tract Morphogenesis
Positive Regulation Of Nitric-oxide Synthase Activity
Cartilage Development
Elastin Metabolic Process
Intestinal Epithelial Cell Maturation
Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
Iris Morphogenesis
Retina Vasculature Development In Camera-type Eye
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of Chemokine-mediated Signaling Pathway
Negative Regulation Of Thymocyte Apoptotic Process
Cellular Response To Interleukin-1
Cellular Response To Hypoxia
Dopaminergic Neuron Differentiation
Hypoxia-inducible Factor-1alpha Signaling Pathway
Cellular Response To Virus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Autophagy Of Mitochondrion
Regulation Of Aerobic Respiration
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of Protein Neddylation
Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways
phospho-PLA2 pathway
RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
Frs2-mediated activation
ERK/MAPK targets
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate NADPH Oxidases
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Neutrophil degranulation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
RUNX2 regulates osteoblast differentiation
Regulation of PTEN gene transcription
Regulation of the apoptosome activity
Estrogen-stimulated signaling through PRKCZ
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Suppression of apoptosis
Signaling downstream of RAS mutants
Signaling by MAP2K mutants
Signaling by MAPK mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
Growth hormone receptor signaling
Regulation of gene expression by Hypoxia-inducible Factor
Cellular response to hypoxia
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
NOTCH1 Intracellular Domain Regulates Transcription
Circadian Clock
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
PTK6 Expression
PTK6 promotes HIF1A stabilization
Neddylation
Drugs
Acetylsalicylic acid
Minocycline
Isoprenaline
Arsenic trioxide
Olomoucine
Phosphonothreonine
Purvalanol
SB220025
Seliciclib
Perifosine
N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE
(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE
(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE
5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE
(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione
[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine
Turpentine
Ulixertinib
Carvedilol
Hydralazine
2-Methoxyestradiol
ENMD-1198
PX-478
FG-2216
Diseases
GWAS
Bipolar disorder (
31043756
)
Body size at age 10 (
32376654
)
Inflammatory bowel disease (
23128233
)
Multiple sclerosis (
31604244
24076602
21833088
)
Superior parietal cortex volume (
31530798
)
Interacting Genes
248 interacting genes:
AR
ARRB1
ARRB2
ATF2
ATP1A1
BANP
BCL2
BCL3
BCL6
BRAF
C1QBP
CACYBP
CAD
CALCOCO1
CAPN2
CASP8
CASP9
CAV1
CD19
CDC25C
CDX2
CEBPB
CEP55
CHN1
CITED2
CMTM3
COPS6
CREBBP
CRP
CSNK2A1
CTNND1
CTSD
CUEDC2
DAPK1
DUSP1
DUSP16
DUSP2
DUSP3
DUSP4
DUSP5
DUSP6
DUSP7
DUSP9
DYRK1B
EGFR
EGLN3
EIF4EBP1
ELK1
ELK4
ENAH
EP300
EPOR
ERF
ESR1
ESR2
ETS1
FCGR2B
FHL3
FOS
FOXO3
FRS2
FRS3
GAB1
GAB2
GABRR1
GAPDH
GATA1
GATA2
GATA4
GJA1
GMFB
GNPTAB
GORASP2
GRB10
GRB2
GSK3B
HDAC4
HDAC6
HIF1A
HNF4A
HOMEZ
HSF1
HSF4
HSP90AA1
ID2
IER3
IFI35
IFNAR1
IQGAP1
IRS1
ITGB6
JUN
JUND
KARS1
KDR
KHDRBS1
KLF11
KRT8
KSR1
KSR2
LAMTOR3
LCK
LIFR
LIPE
LRPAP1
LRRC4
LZTS2
MAFA
MAP2K1
MAP2K2
MAP2K4
MAP2K6
MAP2K7
MAP3K1
MAP3K10
MAPK14
MAPK8
MAPKAPK5
MAPT
MBP
MCL1
MDFI
METAP2
MITF
MKNK1
MKNK2
MSX2
MTIF3
MTPN
MYB
MYC
NCOA1
NCOA3
NDE1
NEFH
NEK2
NGFR
NKX2-1
NOXA1
NR3C1
NR4A1
NR4A2
NR5A1
NRL
NTRK3
NUP153
PAK1
PAK2
PAX5
PDE4D
PEA15
PEBP1
PKM
PLA2G4A
PLAGL2
PLAT
PLCB1
PLK3
POLR2G
PPARA
PPARG
PPP1CA
PPP1R18
PPP1R9B
PPP2CA
PPP2R5B
PPP2R5C
PRDX6
PRKCD
PRKCE
PRKCZ
PRPSAP1
PSMA1
PTPDC1
PTPN1
PTPN5
PTPN7
PTPRC
PTPRE
PTPRH
PTPRR
PXN
RAF1
RB1
REST
RET
RGS19
RNF216
RNF8
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KB1
RPTOR
RUNX1
RXRA
SCNN1G
SH2D3C
SHANK3
SHC1
SLC9A1
SMAD1
SMAD2
SMAD3
SMAD4
SNCA
SNCG
SORBS3
SOS1
SP1
SREBF1
SREBF2
STAT3
STAT5A
STAT5B
STXBP1
STYX
SUPT20H
TCF3
TFCP2
TGIF1
TH
TIAL1
TLE5
TNFRSF1A
TNFRSF25
TNFSF11
TNIP1
TNIP2
TNKS2
TOB1
TOP2A
TP53
TPR
TSC2
TTN
TXNIP
UBE3A
UBR5
UBTF
VAV1
VDR
YBX1
YBX3
ZBTB42
ZC3HC1
ZFP36
125 interacting genes:
AKT1
APEX1
AR
ARNT
ARNT2
ARNTL
ATM
AURKA
BNIP3
CASR
CCND2
CDC34
CDK4
CDK6
CDKN2A
CDKN2B
CITED2
COPS5
CREB3L1
CREBBP
CSNK1D
CSNK2A1
CTNNB1
DAP3
E2F7
EAF2
EGLN1
EGLN2
EGLN3
EIF5A2
EP300
EPHA2
EPO
ESRRA
ESRRB
ESRRG
ETV4
F12
FGFR4
FZR1
GATA3
GLIS2
HDAC1
HDAC2
HDAC3
HDAC5
HIF1A-AS2
HIF1AN
HIF3A
HNF4A
HSP90AA1
IKBKG
ISG15
JUN
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LATS2
LINC01139
LRRK2
MAFG
MAFK
MAP2K3
MAP2K5
MAPK1
MAPK3
MAX
MCL1
MCM7
MDM2
MTA1
MYC
NAA10
NAA11
NBN
NCOA1
NCOA2
NDN
NEDD8
NF2
NQO1
NR4A1
OS9
PER1
PGK1
PKM
PLD1
PLD2
PLK3
PRKACA
PSMA7
PTBP1
PTK6
RACGAP1
RACK1
RB1
RORA
RUNX2
RWDD3
SAT1
SEPTIN9
SIRT2
SMAD3
SP1
SSX4
STAT3
STK11
STUB1
SUCO
SUMO1
TEAD2
TP53
TSGA10
UBE2D1
UBE2I
USP19
USP20
USP28
USP7
VEGFA
VHL
VHLL
ZC3H12A
Entrez ID
5594
3091
HPRD ID
01496
04517
Ensembl ID
ENSG00000100030
ENSG00000100644
Uniprot IDs
P28482
Q1HBJ4
Q499G7
D0VY79
Q16665
PDB IDs
1PME
1TVO
1WZY
2OJG
2OJI
2OJJ
2Y9Q
3D42
3D44
3I5Z
3I60
3SA0
3TEI
3W55
4FMQ
4FUX
4FUY
4FV0
4FV1
4FV2
4FV3
4FV4
4FV5
4FV6
4FV7
4FV8
4FV9
4G6N
4G6O
4H3P
4H3Q
4IZ5
4IZ7
4IZA
4N0S
4NIF
4O6E
4QP1
4QP2
4QP3
4QP4
4QP6
4QP7
4QP8
4QP9
4QPA
4QTA
4QTE
4XJ0
4ZXT
4ZZM
4ZZN
4ZZO
5AX3
5BUE
5BUI
5BUJ
5BVD
5BVE
5BVF
5K4I
5LCJ
5LCK
5NGU
5NHF
5NHH
5NHJ
5NHL
5NHO
5NHP
5NHV
5V60
5V61
5V62
5WP1
6D5Y
6DMG
6G54
6G8X
6G91
6G92
6G93
6G97
6G9A
6G9D
6G9H
6G9J
6G9K
6G9M
6G9N
6GDM
6GDQ
6GE0
6GJB
6GJD
6NBS
6OPG
6OPH
6OPI
6Q7K
6Q7S
6Q7T
6QA1
6QA3
6QA4
6QAG
6QAH
6QAL
6QAQ
6QAW
6RQ4
6SLG
1D7G
1H2K
1H2L
1H2M
1L3E
1L8C
1LM8
1LQB
2ILM
3HQR
3HQU
4AJY
4H6J
5JWP
5L9B
5L9V
5LA9
5LAS
6GFX
6GMR
Enriched GO Terms of Interacting Partners
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