ITIH3 and SPINT2

Data Source:
HPRD (in vivo)

		ITIH3	SPINT2
Description		inter-alpha-trypsin inhibitor heavy chain 3	serine peptidase inhibitor, Kunitz type 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Platelet Dense Granule Lumen Extracellular Exosome	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Platelet Degranulation Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process	Neural Tube Closure Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell-cell Adhesion Epithelial Cell Morphogenesis Involved In Placental Branching Basement Membrane Organization Cellular Response To BMP Stimulus Negative Regulation Of Cell Motility Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		Platelet degranulation	MET Receptor Activation Signaling by MST1
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972 31043756) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Broad depression or bipolar disorder ( 30626913) Broad depression or schizophrenia ( 30626913) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103) Hemoglobin levels ( 32327693) Immune reponse to smallpox (secreted IL-2) ( 22610502) Parkinson's disease ( 28892059) Red blood cell count ( 32888494 27863252) Schizophrenia ( 25056061 21926974 29483656 30285260 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Blood protein levels ( 30072576 29875488) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: EP300 SPINT2	6 interacting genes: APP CTSB HGFAC ITIH2 ITIH3 SUMO4
Entrez ID		3699	10653
HPRD ID		00891	05495
Ensembl ID		ENSG00000162267	ENSG00000167642
Uniprot IDs		Q06033	A0A140VJV6 O43291
PDB IDs			4U32
Enriched GO Terms of Interacting Partners?
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