FCER1A and ITIH2

Data Source:
HPRD (in vitro)

		FCER1A	ITIH2
Description		Fc fragment of IgE receptor Ia	inter-alpha-trypsin inhibitor heavy chain 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding IgE Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune Response	Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Omalizumab Benzylpenicilloyl polylysine TNX-901	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		C-reactive protein ( 22939635) IgE levels ( 18846228 22075330) Obesity-related traits ( 23251661) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Select biomarker traits ( 17903293) White blood cell count ( 27863252)	Blood protein levels ( 29875488) Ovarian reserve ( 22116950)
Interacting Genes		6 interacting genes: FCER1G ITIH2 LMNA MESD MS4A2 PDHB	3 interacting genes: ATP5F1C FCER1A SPINT2
Entrez ID		2205	3698
HPRD ID		00917	00890
Ensembl ID		ENSG00000179639	ENSG00000151655
Uniprot IDs		P12319	P19823
PDB IDs		1ALS 1ALT 1F2Q 1F6A 1J86 1J87 1J88 1J89 1RPQ 2Y7Q
Enriched GO Terms of Interacting Partners?
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