ITGA9 and GPX1

Data Source:
BioGRID (affinity chromatography technology)

		ITGA9	GPX1
Description		integrin subunit alpha 9	glutathione peroxidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Integrin Alpha9-beta1 Complex	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Lewy Body
	Molecular Function	Collagen Binding Laminin Binding Metal Ion Binding	Peroxidase Activity Glutathione Peroxidase Activity SH3 Domain Binding Phospholipid-hydroperoxide Glutathione Peroxidase Activity
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization Wound Healing	Temperature Homeostasis Endothelial Cell Development Negative Regulation Of Inflammatory Response To Antigenic Stimulus Purine Nucleotide Catabolic Process Triglyceride Metabolic Process Glutathione Metabolic Process Sensory Perception Of Sound Response To Xenobiotic Stimulus Response To Symbiotic Bacterium UV Protection Response To Selenium Ion Response To Gamma Radiation Protein Oxidation Arachidonic Acid Metabolic Process Lipoxygenase Pathway Response To Hydroperoxide Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Oxidative Stress Regulation Of Gene Expression, Epigenetic Vasodilation Response To Hydrogen Peroxide Hydrogen Peroxide Catabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Skeletal Muscle Tissue Regeneration Blood Vessel Endothelial Cell Migration Fat Cell Differentiation Cell Redox Homeostasis Skeletal Muscle Fiber Development Myoblast Proliferation Biological Process Involved In Interaction With Symbiont Positive Regulation Of Protein Kinase B Signaling Heart Contraction Angiogenesis Involved In Wound Healing Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Release Of Cytochrome C From Mitochondria Cellular Oxidant Detoxification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization
Pathways		Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1	Synthesis of 5-eicosatetraenoic acids Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism
Drugs			Glutathione Glutathione Glutathione disulfide Cannabidiol Medical Cannabis Nabiximols
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-herpes simplex virus 6 IE1A IgG seropositivity ( 33204752) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Mortality in sepsis ( 27639821) Nasopharyngeal carcinoma ( 19478819) Phospholipid levels (plasma) ( 22359512) Platelet count ( 32888494) PR interval ( 23139255) Pulse pressure ( 30224653 30578418) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 30578418)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908 25082827)
Interacting Genes		6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD	5 interacting genes: ABL1 ABL2 FAM9B MAPK6 SELENBP1
Entrez ID		3680	2876
HPRD ID		04910	11749
Ensembl ID		ENSG00000144668	ENSG00000233276
Uniprot IDs		Q13797 Q8N6H6	A0A2R8Y6B6 P07203 Q7L4Q3
PDB IDs			2F8A
Enriched GO Terms of Interacting Partners?
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