ITGA9 and VEGFD

Data Source:
HPRD (in vivo, in vitro)

		ITGA9	VEGFD
Description		integrin subunit alpha 9	vascular endothelial growth factor D
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Integrin Alpha9-beta1 Complex	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Collagen Binding Laminin Binding Metal Ion Binding	Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 3 Binding
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization Wound Healing	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Platelet Degranulation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Bacterium Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Positive Regulation Of Mast Cell Chemotaxis Dopaminergic Neuron Differentiation
Pathways		Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1	Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy	Gastric cancer
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-herpes simplex virus 6 IE1A IgG seropositivity ( 33204752) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Mortality in sepsis ( 27639821) Nasopharyngeal carcinoma ( 19478819) Phospholipid levels (plasma) ( 22359512) Platelet count ( 32888494) PR interval ( 23139255) Pulse pressure ( 30224653 30578418) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 30578418)
Interacting Genes		6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD	4 interacting genes: FLT4 ITGA9 KDR VAMP3
Entrez ID		3680	2277
HPRD ID		04910	02102
Ensembl ID		ENSG00000144668	ENSG00000165197
Uniprot IDs		Q13797 Q8N6H6	O43915
PDB IDs			2XV7
Enriched GO Terms of Interacting Partners?
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