ITGA9 and NGF

Data Source:
BioGRID (pull down)

		ITGA9	NGF
Description		integrin subunit alpha 9	nerve growth factor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Integrin Alpha9-beta1 Complex	Extracellular Region Extracellular Space Golgi Lumen Cytosol Synaptic Vesicle Axon Dendrite Endosome Lumen
	Molecular Function	Collagen Binding Laminin Binding Metal Ion Binding	Nerve Growth Factor Receptor Binding Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Lipid Binding
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization Wound Healing	Activation Of MAPKK Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peripheral Nervous System Development Memory Negative Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Gene Expression Nerve Development Nerve Growth Factor Processing Positive Regulation Of Peptidyl-serine Phosphorylation Nerve Growth Factor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Collateral Sprouting Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission
Pathways		Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans Signal transduction by L1	PLC-gamma1 signalling Signalling to RAS NGF processing NGF processing Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling Retrograde neurotrophin signalling TRKA activation by NGF TRKA activation by NGF Signalling to p38 via RIT and RIN NRAGE signals death through JNK p75NTR negatively regulates cell cycle via SC1 Ceramide signalling PI3K/AKT activation PI3K/AKT activation Signalling to STAT3 NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation
Drugs			Clenbuterol RI 624 Polaprezinc
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anti-herpes simplex virus 6 IE1A IgG seropositivity ( 33204752) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Mortality in sepsis ( 27639821) Nasopharyngeal carcinoma ( 19478819) Phospholipid levels (plasma) ( 22359512) Platelet count ( 32888494) PR interval ( 23139255) Pulse pressure ( 30224653 30578418) Response to antidepressants (symptom improvement) ( 29160301) Systolic blood pressure ( 30578418)	Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Dysmenorrheic pain ( 27454463) Dysmenorrheic pain severity ( 29855537) Menstruation quality of life impact (dysmenorrhea) ( 29855537) Migraine ( 27182965 27322543) Migraine without aura ( 27322543) Obstetric antiphospholipid syndrome ( 28424481) Pain medicine use during menstruation ( 29855537) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Red blood cell count ( 32888494) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878)
Interacting Genes		6 interacting genes: ITGB1 NGF PXN SAT1 SPP1 VEGFD	11 interacting genes: A2M CRYAB ITGA9 ITGB1 LRP1 MMP7 NGFR NTRK1 PLG SORCS3 SORT1
Entrez ID		3680	4803
HPRD ID		04910	08874
Ensembl ID		ENSG00000144668	ENSG00000134259
Uniprot IDs		Q13797 Q8N6H6	A0A346FYQ1 P01138
PDB IDs			1SG1 1WWW 2IFG 4EDW 4EDX 4ZBN 5JZ7
Enriched GO Terms of Interacting Partners?
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