AR and MED1

Data Source:
HPRD (in vivo, in vitro)

		AR	MED1
Description		androgen receptor	mediator complex subunit 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Protein-containing Complex	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Androgen Binding Protein Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding ATPase Binding POU Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding LBD Domain Binding Ubiquitin Protein Ligase Activity Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Regulation Of Systemic Arterial Blood Pressure Epithelial Cell Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Spermatogenesis Single Fertilization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Positive Regulation Of Gene Expression Protein Deubiquitination Male Somatic Sex Determination Intracellular Steroid Hormone Receptor Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Leydig Cell Differentiation Multicellular Organism Growth Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Negative Regulation Of Integrin Biosynthetic Process Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Developmental Growth Animal Organ Formation Male Genitalia Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Activation Of Prostate Induction By Androgen Receptor Signaling Pathway Morphogenesis Of An Epithelial Fold Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Gland Growth Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Testosterone Stimulus Seminiferous Tubule Development Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Protein Import Into Nucleus Androgen Biosynthetic Process Brain Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Regulation Of Lipid Metabolic Process Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Enucleate Erythrocyte Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Generic Transcription Pathway Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression
Drugs		Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Flutamide Oxandrolone Fluphenazine Testosterone Mitotane Estrone Nilutamide Tamoxifen Norethisterone Drostanolone Norgestimate Nandrolone phenpropionate Ketoconazole Acetophenazine Bicalutamide Fluoxymesterone Drospirenone Danazol Testosterone propionate Oxybenzone 1-Testosterone Boldenone Calusterone Periciazine Prasterone Flufenamic acid Stanolone (R)-Bicalutamide Metribolone (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE Cyproterone acetate LGD2941 Dimethylcurcumin Oxymetholone Methyltestosterone Norelgestromin Stanozolol Tetrahydrogestrinone (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide BMS-564929 S-23 phenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide Andarine (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile LGD-2226 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL Triclosan Nandrolone decanoate Ulipristal Enzalutamide Eugenol Dienogest Norethynodrel Norgestrel Homosalate Enzacamene Mibolerone Phenothiazine Gestrinone Apalutamide Clascoterone Darolutamide Esculin Ligandrol Testosterone cypionate Testosterone enanthate Testosterone undecanoate Stanolone acetate Segesterone acetate Boldenone undecylenate Echinacoside Ketodarolutamide	Becocalcidiol
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism Prostate cancer Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
GWAS		Balding ( 26926045) Excessive daytime sleepiness ( 27992416) LDL cholesterol ( 19060910) Male-pattern baldness ( 29146897 22693459 27182965 22032556 18849991 28196072) Prostate cancer ( 21743467)	Asthma ( 31619474) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Lung function (FVC) ( 30061609) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 20228799)
Interacting Genes		265 interacting genes: ABL1 ABL2 ACTB AHR AKT1 APOL2 APPBP2 ARID5A ATF2 BAG1 BLK BLNK BRCA1 BTK CACUL1 CALM1 CALR CASP1 CASP3 CASP7 CASP8 CAV1 CCAR2 CCND1 CCNE1 CCNH CDC25A CDC25B CDC37 CDK1 CDK6 CDK7 CDK9 CEBPA CEBPB CHD8 COX5B CREBBP CRK CTDSP2 CTNNB1 CUL4B DAP3 DAXX DCAF6 DCC DDB2 DDC DENND5A EED EFCAB6 EGFR ELF3 EP300 ERCC2 ERCC3 ESR1 ETV5 EZH2 FES FGR FHL2 FLNA FOXA1 FOXG1 FOXO1 GADD45GIP1 GAK GAPDH GLI2 GRAP2 GRB2 GRB7 GRIP1 GSK3B GSN GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 HCK HDAC1 HDAC3 HDAC4 HIF1A HIPK3 HMGB1 HMGB2 HOTAIR HSH2D HSP90AA1 IARS1 IDE IFI16 IL6ST INPPL1 JMJD1C JUN KAT2B KAT5 KAT7 KDM1A KIF1A KIFAP3 KLK2 LCK LCOR LYN MAGEA11 MAPK1 MATK MDM2 MDN1 MED1 MED12L MED14 MED24 MLH3 MYBBP1A MYLIP NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NDE1 NELFCD NFKB1 NISCH NLRP10 NONO NR0B1 NR0B2 NR2C1 NR2C2 NR3C1 NR3C2 NR5A1 NRIP1 NSD1 NSD2 PA2G4 PAK6 PELP1 PIAS1 PIAS2 PIAS3 PIAS4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PNRC1 PNRC2 POU2F1 POU2F2 POU5F1 PRKG1 PRMT1 PRPF6 PSMC3IP PTEN PTK6 PTPN11 PXN RAC3 RACK1 RAD54L2 RAD9A RAF1 RAN RANBP9 RASA1 RB1 RBAK RCHY1 REL RELA REPS2 RNASEL RNF14 RNF4 RNF6 RUNX1 RUNX2 SART3 SFPQ SH2D1A SH2D1B SH2D2A SH2D3C SH3YL1 SHB SHC1 SHC3 SHC4 SHE SIRT1 SLC25A4 SMAD1 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCE1 SOCS3 SOCS6 SP1 SPDEF SPOP SRC SREBF1 SRY STAP1 STAT3 STUB1 SUMO1 SUV39H2 SVIL SYK TADA3 TAF1 TBP TCF20 TCF4 TCF7L2 TDG TGFB1I1 TGIF1 TLE5 TMF1 TNK2 TNS1 TNS4 TPD52 TRIM24 TRIP4 TSG101 TXNDC5 UBE2I UBE3A USP10 UXT VAV1 VAV2 VAV3 VCP VHL WIPI1 XRCC5 XRCC6 YES1 YWHAQ ZBTB1 ZBTB16 ZBTB32 ZBTB7A ZMIZ1 ZMIZ2 ZNF451	46 interacting genes: AKAP9 AR BRCA1 CASK CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MAPK3 MDM2 MED12 MED14 MED25 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RBM5 RORA RPA2 RXRA SREBF1 TET2 THRA THRB TP53 VDR YWHAH YWHAQ
Entrez ID		367	5469
HPRD ID		02437	05055
Ensembl ID		ENSG00000169083	ENSG00000125686
Uniprot IDs		A0A087WUX9 F1D8N5 G4VV16 P10275 Q9NUA2	Q15648
PDB IDs		1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA 2HVC 2OZ7 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2PNU 2Q7I 2Q7J 2Q7K 2Q7L 2YHD 2YLO 2YLP 2YLQ 2Z4J 3B5R 3B65 3B66 3B67 3B68 3BTR 3L3X 3L3Z 3RLJ 3RLL 3V49 3V4A 3ZQT 4HLW 4K7A 4OEA 4OED 4OEY 4OEZ 4OFR 4OFU 4OGH 4OH5 4OH6 4OHA 4OIL 4OIU 4OJ9 4OJB 4OK1 4OKB 4OKT 4OKW 4OKX 4OLM 4QL8 5CJ6 5JJM 5T8E 5T8J 5V8Q 5VO4	1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W0G 3W0H 3W0I 3W0J 3W5P 3W5Q 3W5R 3W5T 3WT5 3WT6 3WT7 3WTQ 4YNK 5AWJ 5AWK 5B41 5B5B 5GIC 5GID 5GIE 5XPM 5XPN 5XPO 5XPP 5XUQ 5XZF 5XZH 5ZWE 5ZWF 5ZWH 5ZWI 6D94 6JEZ 6K5O 6ONJ
Enriched GO Terms of Interacting Partners?
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