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AR and IL6ST
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
AR
IL6ST
Description
androgen receptor
interleukin 6 cytokine family signal transducer
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Speck
Protein-containing Complex
Extracellular Region
Plasma Membrane
Interleukin-6 Receptor Complex
Oncostatin-M Receptor Complex
External Side Of Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
Extracellular Exosome
Ciliary Neurotrophic Factor Receptor Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II General Transcription Initiation Factor Binding
RNA Polymerase II Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Steroid Binding
Androgen Binding
Protein Binding
Beta-catenin Binding
Transcription Factor Binding
Zinc Ion Binding
Enzyme Binding
ATPase Binding
POU Domain Binding
Cytokine Receptor Activity
Ciliary Neurotrophic Factor Receptor Activity
Interleukin-6 Receptor Activity
Interleukin-11 Receptor Activity
Leukemia Inhibitory Factor Receptor Activity
Oncostatin-M Receptor Activity
Ciliary Neurotrophic Factor Receptor Binding
Interleukin-6 Receptor Binding
Protein Binding
Growth Factor Binding
Cytokine Binding
Interleukin-11 Binding
Interleukin-6 Binding
Identical Protein Binding
Interleukin-27 Receptor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Regulation Of Systemic Arterial Blood Pressure
Epithelial Cell Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Cell-cell Signaling
Spermatogenesis
Single Fertilization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Positive Regulation Of Gene Expression
Protein Deubiquitination
Male Somatic Sex Determination
Intracellular Steroid Hormone Receptor Signaling Pathway
Intracellular Estrogen Receptor Signaling Pathway
Androgen Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Leydig Cell Differentiation
Multicellular Organism Growth
Positive Regulation Of Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Differentiation
Negative Regulation Of Integrin Biosynthetic Process
Positive Regulation Of Integrin Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
Regulation Of Developmental Growth
Animal Organ Formation
Male Genitalia Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Activation Of Prostate Induction By Androgen Receptor Signaling Pathway
Morphogenesis Of An Epithelial Fold
Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis
Prostate Gland Growth
Prostate Gland Epithelium Morphogenesis
Epithelial Cell Differentiation Involved In Prostate Gland Development
Tertiary Branching Involved In Mammary Gland Duct Morphogenesis
Mammary Gland Alveolus Development
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Testosterone Stimulus
Seminiferous Tubule Development
Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Acute Inflammatory Response
Positive Regulation Of Adaptive Immune Response
Glycogen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Cardiac Muscle Hypertrophy
Viral Process
Cytokine-mediated Signaling Pathway
Response To Cytokine
Interleukin-11-mediated Signaling Pathway
Oncostatin-M-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Astrocyte Differentiation
Leukemia Inhibitory Factor Signaling Pathway
Intestinal Epithelial Cell Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Pathways
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
RUNX2 regulates osteoblast differentiation
RUNX2 regulates osteoblast differentiation
Interleukin-6 signaling
Interleukin-6 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling
Interleukin-27 signaling
Interleukin-27 signaling
Drugs
Diethylstilbestrol
Levonorgestrel
Progesterone
Spironolactone
Flutamide
Oxandrolone
Fluphenazine
Testosterone
Mitotane
Estrone
Nilutamide
Tamoxifen
Norethisterone
Drostanolone
Norgestimate
Nandrolone phenpropionate
Ketoconazole
Acetophenazine
Bicalutamide
Fluoxymesterone
Drospirenone
Danazol
Testosterone propionate
Oxybenzone
1-Testosterone
Boldenone
Calusterone
Periciazine
Prasterone
Flufenamic acid
Stanolone
(R)-Bicalutamide
Metribolone
(3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
Cyproterone acetate
LGD2941
Dimethylcurcumin
Oxymetholone
Methyltestosterone
Norelgestromin
Stanozolol
Tetrahydrogestrinone
(2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
BMS-564929
S-23
phenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
(2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
Andarine
(R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
(5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
LGD-2226
3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
Triclosan
Nandrolone decanoate
Ulipristal
Enzalutamide
Eugenol
Dienogest
Norethynodrel
Norgestrel
Homosalate
Enzacamene
Mibolerone
Phenothiazine
Gestrinone
Apalutamide
Clascoterone
Darolutamide
Esculin
Ligandrol
Testosterone cypionate
Testosterone enanthate
Testosterone undecanoate
Stanolone acetate
Segesterone acetate
Boldenone undecylenate
Echinacoside
Ketodarolutamide
Diseases
46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
Prostate cancer
Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
GWAS
Balding (
26926045
)
Excessive daytime sleepiness (
27992416
)
LDL cholesterol (
19060910
)
Male-pattern baldness (
29146897
22693459
27182965
22032556
18849991
28196072
)
Prostate cancer (
21743467
)
Blood protein levels (
30072576
29875488
28240269
)
Crohn's disease (
23128233
)
IgG glycosylation (
23382691
)
Mean spheric corpuscular volume (
32888494
)
Rheumatoid arthritis (
20453842
)
Interacting Genes
265 interacting genes:
ABL1
ABL2
ACTB
AHR
AKT1
APOL2
APPBP2
ARID5A
ATF2
BAG1
BLK
BLNK
BRCA1
BTK
CACUL1
CALM1
CALR
CASP1
CASP3
CASP7
CASP8
CAV1
CCAR2
CCND1
CCNE1
CCNH
CDC25A
CDC25B
CDC37
CDK1
CDK6
CDK7
CDK9
CEBPA
CEBPB
CHD8
COX5B
CREBBP
CRK
CTDSP2
CTNNB1
CUL4B
DAP3
DAXX
DCAF6
DCC
DDB2
DDC
DENND5A
EED
EFCAB6
EGFR
ELF3
EP300
ERCC2
ERCC3
ESR1
ETV5
EZH2
FES
FGR
FHL2
FLNA
FOXA1
FOXG1
FOXO1
GADD45GIP1
GAK
GAPDH
GLI2
GRAP2
GRB2
GRB7
GRIP1
GSK3B
GSN
GTF2F1
GTF2F2
GTF2H1
GTF2H2
GTF2H3
HCK
HDAC1
HDAC3
HDAC4
HIF1A
HIPK3
HMGB1
HMGB2
HOTAIR
HSH2D
HSP90AA1
IARS1
IDE
IFI16
IL6ST
INPPL1
JMJD1C
JUN
KAT2B
KAT5
KAT7
KDM1A
KIF1A
KIFAP3
KLK2
LCK
LCOR
LYN
MAGEA11
MAPK1
MATK
MDM2
MDN1
MED1
MED12L
MED14
MED24
MLH3
MYBBP1A
MYLIP
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NDE1
NELFCD
NFKB1
NISCH
NLRP10
NONO
NR0B1
NR0B2
NR2C1
NR2C2
NR3C1
NR3C2
NR5A1
NRIP1
NSD1
NSD2
PA2G4
PAK6
PELP1
PIAS1
PIAS2
PIAS3
PIAS4
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PNRC1
PNRC2
POU2F1
POU2F2
POU5F1
PRKG1
PRMT1
PRPF6
PSMC3IP
PTEN
PTK6
PTPN11
PXN
RAC3
RACK1
RAD54L2
RAD9A
RAF1
RAN
RANBP9
RASA1
RB1
RBAK
RCHY1
REL
RELA
REPS2
RNASEL
RNF14
RNF4
RNF6
RUNX1
RUNX2
SART3
SFPQ
SH2D1A
SH2D1B
SH2D2A
SH2D3C
SH3YL1
SHB
SHC1
SHC3
SHC4
SHE
SIRT1
SLC25A4
SMAD1
SMAD3
SMAD4
SMARCA2
SMARCA4
SMARCD1
SMARCE1
SOCS3
SOCS6
SP1
SPDEF
SPOP
SRC
SREBF1
SRY
STAP1
STAT3
STUB1
SUMO1
SUV39H2
SVIL
SYK
TADA3
TAF1
TBP
TCF20
TCF4
TCF7L2
TDG
TGFB1I1
TGIF1
TLE5
TMF1
TNK2
TNS1
TNS4
TPD52
TRIM24
TRIP4
TSG101
TXNDC5
UBE2I
UBE3A
USP10
UXT
VAV1
VAV2
VAV3
VCP
VHL
WIPI1
XRCC5
XRCC6
YES1
YWHAQ
ZBTB1
ZBTB16
ZBTB32
ZBTB7A
ZMIZ1
ZMIZ2
ZNF451
34 interacting genes:
AR
CDK9
CMYA5
CNTF
CNTFR
CTF1
ERBB2
ERBB3
HCK
IL31RA
IL6
IL6R
JAK1
KCNIP1
KCNIP3
LIF
LIFR
MAGEA11
OSM
OSMR
PIK3CG
PLAUR
PRKCD
PTPN11
PTPN6
SGTA
SGTB
SHC1
SOCS3
STAT3
TLE1
TYK2
UBQLN1
VAV1
Entrez ID
367
3572
HPRD ID
02437
02824
Ensembl ID
ENSG00000169083
ENSG00000134352
Uniprot IDs
A0A087WUX9
F1D8N5
G4VV16
P10275
Q9NUA2
A0A0A0N0L2
P40189
Q17RA0
PDB IDs
1E3G
1GS4
1T5Z
1T63
1T65
1XJ7
1XOW
1XQ3
1Z95
2AM9
2AMA
2AMB
2AO6
2AX6
2AX7
2AX8
2AX9
2AXA
2HVC
2OZ7
2PIO
2PIP
2PIQ
2PIR
2PIT
2PIU
2PIV
2PIW
2PIX
2PKL
2PNU
2Q7I
2Q7J
2Q7K
2Q7L
2YHD
2YLO
2YLP
2YLQ
2Z4J
3B5R
3B65
3B66
3B67
3B68
3BTR
3L3X
3L3Z
3RLJ
3RLL
3V49
3V4A
3ZQT
4HLW
4K7A
4OEA
4OED
4OEY
4OEZ
4OFR
4OFU
4OGH
4OH5
4OH6
4OHA
4OIL
4OIU
4OJ9
4OJB
4OK1
4OKB
4OKT
4OKW
4OKX
4OLM
4QL8
5CJ6
5JJM
5T8E
5T8J
5V8Q
5VO4
1BJ8
1BQU
1I1R
1N2Q
1P9M
1PVH
3L5H
3L5I
3L5J
Enriched GO Terms of Interacting Partners
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