MED1 and VDR

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vivo, in vitro)

		MED1	VDR
Description		mediator complex subunit 1	vitamin D receptor
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Chromatin Nucleus Nucleoplasm Nucleolus Membrane Mediator Complex Protein-DNA Complex	Chromatin Nucleus Nucleoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Thyroid Hormone Receptor Binding LBD Domain Binding Ubiquitin Protein Ligase Activity Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Lithocholic Acid Receptor Activity Retinoid X Receptor Binding Vitamin D Response Element Binding Calcitriol Binding Lithocholic Acid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Angiogenesis Liver Development Embryonic Placenta Development Lens Development In Camera-type Eye Thyroid Hormone Mediated Signaling Pathway Ventricular Trabecula Myocardium Morphogenesis Retinal Pigment Epithelium Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Thyroid Hormone Generation Protein Import Into Nucleus Androgen Biosynthetic Process Brain Development Lactation Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Regulation Of Lipid Metabolic Process Keratinocyte Differentiation Monocyte Differentiation Intracellular Steroid Hormone Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Development Embryonic Hindlimb Morphogenesis Embryonic Hemopoiesis Peroxisome Proliferator Activated Receptor Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Megakaryocyte Development MRNA Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of Keratinocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Erythrocyte Development Enucleate Erythrocyte Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Mammary Gland Branching Involved In Thelarche Mammary Gland Branching Involved In Pregnancy Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of G0 To G1 Transition Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Thyroid Hormone Stimulus Positive Regulation Of Hepatocyte Proliferation Regulation Of RNA Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Bile Acid Signaling Pathway Vitamin D Metabolic Process Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Decidualization Regulation Of Calcidiol 1-monooxygenase Activity Vitamin D Receptor Signaling Pathway
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Generic Transcription Pathway Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Estrogen-dependent gene expression	Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs		Becocalcidiol	Calcitriol Calcifediol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol Lexacalcitol Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Elocalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin Curcumin sulfate
Diseases			Tuberculosis Localized autosomal recessive hypotrichosis
GWAS		Asthma ( 31619474) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Lung function (FVC) ( 30061609) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 20228799)	Asthma (adult onset) ( 31036433) Eosinophil percentage of white cells ( 32888494) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870) Serum immune biomarker levels ( 32066700)
Interacting Genes		46 interacting genes: AKAP9 AR BRCA1 CASK CTDP1 ESR1 ESR2 EZH2 GABPA GATA1 GATA3 GATA4 GATA6 GJB5 HNF4A KIF1A MAPK3 MDM2 MED12 MED14 MED25 MED8 MED9 MYC NCOA6 NR1H2 NR1I3 NR3C1 NR4A1 PIN1 PPARA PPARG PPARGC1A RARA RBM5 RORA RPA2 RXRA SREBF1 TET2 THRA THRB TP53 VDR YWHAH YWHAQ	79 interacting genes: ACTN4 ACVR1 ANKRD11 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NLRP3 NR0B2 NR1H2 NRIP1 NSD1 NTAQ1 OTUD4 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RPS6KC1 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 ZBTB16
Entrez ID		5469	7421
HPRD ID		05055	03463
Ensembl ID		ENSG00000125686	ENSG00000111424
Uniprot IDs		Q15648	F1D8P8 P11473
PDB IDs		1RJK 1RK3 1RKG 1RKH 2O4J 2O4R 2ZFX 3A2H 3AUN 3VJS 3VJT 3VRT 3VRU 3VRV 3VRW 3W0G 3W0H 3W0I 3W0J 3W5P 3W5Q 3W5R 3W5T 3WT5 3WT6 3WT7 3WTQ 4YNK 5AWJ 5AWK 5B41 5B5B 5GIC 5GID 5GIE 5XPM 5XPN 5XPO 5XPP 5XUQ 5XZF 5XZH 5ZWE 5ZWF 5ZWH 5ZWI 6D94 6JEZ 6K5O 6ONJ	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2
Enriched GO Terms of Interacting Partners?
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