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IL6ST
Description
interleukin 6 cytokine family signal transducer
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Interleukin-6 Receptor Complex
Oncostatin-M Receptor Complex
External Side Of Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Receptor Complex
Extracellular Exosome
Ciliary Neurotrophic Factor Receptor Complex
Molecular Function
Cytokine Receptor Activity
Ciliary Neurotrophic Factor Receptor Activity
Interleukin-6 Receptor Activity
Interleukin-11 Receptor Activity
Leukemia Inhibitory Factor Receptor Activity
Oncostatin-M Receptor Activity
Ciliary Neurotrophic Factor Receptor Binding
Interleukin-6 Receptor Binding
Protein Binding
Growth Factor Binding
Cytokine Binding
Interleukin-11 Binding
Interleukin-6 Binding
Identical Protein Binding
Interleukin-27 Receptor Activity
Biological Process
Positive Regulation Of Acute Inflammatory Response
Positive Regulation Of Adaptive Immune Response
Glycogen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Cardiac Muscle Hypertrophy
Viral Process
Cytokine-mediated Signaling Pathway
Response To Cytokine
Interleukin-11-mediated Signaling Pathway
Oncostatin-M-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Astrocyte Differentiation
Leukemia Inhibitory Factor Signaling Pathway
Intestinal Epithelial Cell Development
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Ciliary Neurotrophic Factor-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Pathways
Interleukin-6 signaling
Interleukin-6 signaling
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling
Interleukin-27 signaling
Interleukin-27 signaling
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Crohn's disease (
23128233
)
IgG glycosylation (
23382691
)
Mean spheric corpuscular volume (
32888494
)
Rheumatoid arthritis (
20453842
)
Interacting Genes
34 interacting genes:
AR
CDK9
CMYA5
CNTF
CNTFR
CTF1
ERBB2
ERBB3
HCK
IL31RA
IL6
IL6R
JAK1
KCNIP1
KCNIP3
LIF
LIFR
MAGEA11
OSM
OSMR
PIK3CG
PLAUR
PRKCD
PTPN11
PTPN6
SGTA
SGTB
SHC1
SOCS3
STAT3
TLE1
TYK2
UBQLN1
VAV1
Entrez ID
3572
HPRD ID
02824
Ensembl ID
ENSG00000134352
Uniprot IDs
A0A0A0N0L2
P40189
Q17RA0
PDB IDs
1BJ8
1BQU
1I1R
1N2Q
1P9M
1PVH
3L5H
3L5I
3L5J
Enriched GO Terms of Interacting Partners
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Tagcloud
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