IRF4 and TLK2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRF4	TLK2
Description		interferon regulatory factor 4	tousled like kinase 2
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Cytosol Membrane	Nucleus Intermediate Filament Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis	Regulation Of Chromatin Assembly Or Disassembly Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Chromosome Segregation Negative Regulation Of Autophagy Peptidyl-serine Phosphorylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Cellular Response To Gamma Radiation
Pathways		Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling
Drugs			Fostamatinib
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus EA-D antibody levels ( 33204752) Eye color ( 20585627 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 30664655 29662168 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Membranous nephropathy ( 32231244) Monobrow ( 27182965) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Non-melanoma skin cancer ( 23548203 29739929) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 25574825 23143594) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Systemic lupus erythematosus ( 33536424) Tanning ( 23548203) Vitiligo ( 27723757) White blood cell count ( 32888494) Youthful appearance (self-reported) ( 32339537)	Heel bone mineral density ( 30598549) Lifespan ( 25918517)
Interacting Genes		22 interacting genes: BATF BCL6 ELP1 ETV7 FKBP4 GIPC2 HOXB13 HOXC11 IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 TSEN54 USP4 YTHDC2	17 interacting genes: ASF1A ASF1B AURKA CEP70 DMAP1 FEZ1 FEZ2 FRMD6 GMCL1 IRF4 IRF7 MBP PAX5 PAX6 TLK1 UBE2I YWHAZ
Entrez ID		3662	11011
HPRD ID		03543	10527
Ensembl ID		ENSG00000137265	ENSG00000146872
Uniprot IDs		Q15306	B4DUC2 J3QLK5 Q86UE8
PDB IDs		2DLL	5O0Y
Enriched GO Terms of Interacting Partners?
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