IRF4 and TOP1

Data Source:
BioGRID (unspecified method)

		IRF4	TOP1
Description		interferon regulatory factor 4	DNA topoisomerase I
Image
GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Cytosol Membrane	Nuclear Chromosome P-body Fibrillar Center Nucleus Nucleoplasm Nucleolus Protein-DNA Complex Perikaryon
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding RNA Binding DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Domain Specific Binding Supercoiled DNA Binding
	Biological Process	Immune System Process Regulation Of Transcription By RNA Polymerase II Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis	DNA Replication DNA Topological Change Chromatin Remodeling Chromosome Segregation Circadian Rhythm Programmed Cell Death Viral Process Phosphorylation Peptidyl-serine Phosphorylation Circadian Regulation Of Gene Expression Embryonic Cleavage Response To Drug
Pathways		Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling	SUMOylation of DNA replication proteins
Drugs			Irinotecan Topotecan Camptothecin Edotecarin Lucanthone Elsamitrucin 7-ethyl-10-hydroxycamptothecin Sodium stibogluconate Cositecan XMT-1001 Rubitecan 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Hexylresorcinol Sacituzumab govitecan Trastuzumab deruxtecan
Diseases
GWAS		Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 18758461 28165464 26956414 24292274 23770605) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus EA-D antibody levels ( 33204752) Eye color ( 20585627 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627 30664655 29662168 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Membranous nephropathy ( 32231244) Monobrow ( 27182965) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Non-melanoma skin cancer ( 23548203 29739929) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 25574825 23143594) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Sunburns ( 23548203) Systemic lupus erythematosus ( 33536424) Tanning ( 23548203) Vitiligo ( 27723757) White blood cell count ( 32888494) Youthful appearance (self-reported) ( 32339537)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 24097068 20686565) Hemoglobin ( 32888494) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Urate levels ( 31578528)
Interacting Genes		22 interacting genes: BATF BCL6 ELP1 ETV7 FKBP4 GIPC2 HOXB13 HOXC11 IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 TSEN54 USP4 YTHDC2	60 interacting genes: APAF1 APP ATM BARD1 BRCA1 BRD2 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PRKDC PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5 XRCC6
Entrez ID		3662	7150
HPRD ID		03543	00535
Ensembl ID		ENSG00000137265	ENSG00000198900
Uniprot IDs		Q15306	P11387 Q9BVT2
PDB IDs		2DLL	1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8
Enriched GO Terms of Interacting Partners?
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