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IRAK1 and TIFA
Data Source:
HPRD
(in vitro, in vivo)
IRAK1
TIFA
Description
interleukin 1 receptor associated kinase 1
TRAF interacting protein with forkhead associated domain
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Protein-containing Complex
Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Biological Process
Activation Of MAPK Activity
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Aging
Viral Process
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Protein Homooligomerization
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Alpha-protein kinase 1 signaling pathway
Drugs
Fostamatinib
Diseases
GWAS
Celiac disease (
22057235
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
26606652
26663301
26502338
19838195
)
Body mass index (
26426971
)
Rheumatoid arthritis (
30891314
)
Interacting Genes
49 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
H3-4
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP3CB
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TICAM2
TIFA
TIRAP
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
YTHDC2
23 interacting genes:
AP1M1
ARHGEF39
DVL2
GSDME
IRAK1
KANK2
LNX1
LNX2
NIF3L1
NTAQ1
NUDT18
NXF1
PRKAA2
RIPPLY3
RPL9
SDCBP
SDCBP2
TIFAB
TNFAIP8
TRAF1
TRAF2
TRAF6
TXN2
Entrez ID
3654
92610
HPRD ID
02235
09835
Ensembl ID
ENSG00000184216
ENSG00000145365
Uniprot IDs
D3YTB5
P51617
Q96CG3
PDB IDs
6BFN
4YM4
4ZGI
5ZUJ
6A33
Enriched GO Terms of Interacting Partners
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