TIFA and TNFAIP8

Data Source:
BioGRID (two hybrid)

		TIFA	TNFAIP8
Description		TRAF interacting protein with forkhead associated domain	TNF alpha induced protein 8
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Homooligomerization	Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		Alpha-protein kinase 1 signaling pathway	PI Metabolism
Drugs
Diseases
GWAS		Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 31361310 31959851 32296059 31619474) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heschl's gyrus morphology ( 25130324) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Plantar fascial disorders ( 29534260) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 28552196 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494)
Interacting Genes		23 interacting genes: AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2	10 interacting genes: ATN1 EAF1 EAPP INO80E MED4 PLEKHF1 PLEKHF2 PRR13 SDCBP TIFA
Entrez ID		92610	25816
HPRD ID		09835	18204
Ensembl ID		ENSG00000145365	ENSG00000145779
Uniprot IDs		Q96CG3	B3KUI2 O95379
PDB IDs		4YM4 4ZGI 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?
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