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IRAK1 and TICAM2
Data Source:
HPRD
(in vitro, in vivo)
IRAK1
TICAM2
Description
interleukin 1 receptor associated kinase 1
toll like receptor adaptor molecule 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Endosome Membrane
Protein-containing Complex
Phagocytic Cup
Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Golgi Apparatus
Plasma Membrane
Endosome Membrane
COPII-coated ER To Golgi Transport Vesicle
Secretory Granule Membrane
Early Endosome Membrane
Late Endosome Membrane
Cell Projection
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Biological Process
Activation Of MAPK Activity
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Activation Of NF-kappaB-inducing Kinase Activity
JNK Cascade
Aging
Viral Process
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of MAP Kinase Activity
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
MyD88-independent Toll-like Receptor Signaling Pathway
Intracellular Protein Transport
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Phagocytosis
Inflammatory Response
Golgi Organization
I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAM-dependent Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Neutrophil Degranulation
Innate Immune Response
Necroptotic Process
Cellular Response To Lipopolysaccharide
Apoptotic Signaling Pathway
Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Caspase activation via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Neutrophil degranulation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Fostamatinib
Diseases
GWAS
Celiac disease (
22057235
)
Lymphocyte counts (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
26606652
26663301
26502338
19838195
)
Allergic disease (asthma, hay fever or eczema) (
29679657
)
Response to antidepressants (symptom improvement) (
29160301
)
Interacting Genes
49 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
H3-4
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP3CB
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TICAM2
TIFA
TIRAP
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
YTHDC2
19 interacting genes:
FTH1
IL1R1
IL1RAP
IRAK1
IRAK2
IRAK3
IRAK4
IRF3
IRF7
MEOX2
NTAQ1
OPN1LW
PIAS2
SARM1
TICAM1
TIRAP
TLR3
TLR4
TRAF6
Entrez ID
3654
353376
HPRD ID
02235
16313
Ensembl ID
ENSG00000184216
ENSG00000243414
Uniprot IDs
D3YTB5
P51617
Q86XR7
PDB IDs
6BFN
2M1W
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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