TICAM2 and IL1RAP

Data Source:
HPRD (in vitro)

		TICAM2	IL1RAP
Description		toll like receptor adaptor molecule 2	interleukin 1 receptor accessory protein
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GO Annotations	Cellular Component	Phagocytic Cup Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Endosome Membrane COPII-coated ER To Golgi Transport Vesicle Secretory Granule Membrane Early Endosome Membrane Late Endosome Membrane Cell Projection	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	MyD88-independent Toll-like Receptor Signaling Pathway Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phagocytosis Inflammatory Response Golgi Organization I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway TRAM-dependent Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neutrophil Degranulation Innate Immune Response Necroptotic Process Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88-independent TLR4 cascade TRIF-mediated programmed cell death Neutrophil degranulation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Response to antidepressants (symptom improvement) ( 29160301)	Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		19 interacting genes: FTH1 IL1R1 IL1RAP IRAK1 IRAK2 IRAK3 IRAK4 IRF3 IRF7 MEOX2 NTAQ1 OPN1LW PIAS2 SARM1 TICAM1 TIRAP TLR3 TLR4 TRAF6	20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		353376	3556
HPRD ID		16313	04021
Ensembl ID		ENSG00000243414	ENSG00000196083
Uniprot IDs		Q86XR7	A8K6K4 Q9NPH3
PDB IDs		2M1W	3O4O 4DEP
Enriched GO Terms of Interacting Partners?
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